ID   ECHA6_MYCTO             Reviewed;         243 AA.
AC   P9WNP0; L0T7V5; P64014; Q10533;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Probable enoyl-CoA hydratase echA6;
DE            EC=4.2.1.17;
GN   Name=echA6; OrderedLocusNames=MT0928;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Could possibly oxidize fatty acids using specific components.
CC       {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O;
CC         Xref=Rhea:RHEA:16105, ChEBI:CHEBI:15377, ChEBI:CHEBI:57318,
CC         ChEBI:CHEBI:58856; EC=4.2.1.17;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O;
CC         Xref=Rhea:RHEA:20724, ChEBI:CHEBI:15377, ChEBI:CHEBI:58521,
CC         ChEBI:CHEBI:137480; EC=4.2.1.17;
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK45175.1; -; Genomic_DNA.
DR   PIR; F70783; F70783.
DR   RefSeq; WP_003404702.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WNP0; -.
DR   SMR; P9WNP0; -.
DR   EnsemblBacteria; AAK45175; AAK45175; MT0928.
DR   KEGG; mtc:MT0928; -.
DR   PATRIC; fig|83331.31.peg.997; -.
DR   HOGENOM; CLU_009834_7_2_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0004300; F:enoyl-CoA hydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR018376; Enoyl-CoA_hyd/isom_CS.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
DR   PROSITE; PS00166; ENOYL_COA_HYDRATASE; 1.
PE   3: Inferred from homology;
KW   Fatty acid metabolism; Lipid metabolism; Lyase.
FT   CHAIN           1..243
FT                   /note="Probable enoyl-CoA hydratase echA6"
FT                   /id="PRO_0000427093"
SQ   SEQUENCE   243 AA;  26029 MW;  23BD1153F0159991 CRC64;
     MIGITQAEAV LTIELQRPER RNALNSQLVE ELTQAIRKAG DGSARAIVLT GQGTAFCAGA
     DLSGDAFAAD YPDRLIELHK AMDASPMPVV GAINGPAIGA GLQLAMQCDL RVVAPDAFFQ
     FPTSKYGLAL DNWSIRRLSS LVGHGRARAM LLSAEKLTAE IALHTGMANR IGTLADAQAW
     AAEIARLAPL AIQHAKRVLN DDGAIEEAWP AHKELFDKAW GSQDVIEAQV ARMEKRPPKF
     QGA