ID   ECHD3_DANRE             Reviewed;         289 AA.
AC   A0PJR5;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 2.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Enoyl-CoA hydratase domain-containing protein 3, mitochondrial;
DE   Flags: Precursor;
GN   Name=echdc3; ORFNames=zgc:158321;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in fatty acid biosynthesis and insulin
CC       sensitivity. {ECO:0000250|UniProtKB:Q96DC8}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAI27584.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BC127583; AAI27584.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001073131.1; NM_001079663.1.
DR   AlphaFoldDB; A0PJR5; -.
DR   SMR; A0PJR5; -.
DR   STRING; 7955.ENSDARP00000087743; -.
DR   PaxDb; A0PJR5; -.
DR   PeptideAtlas; A0PJR5; -.
DR   PRIDE; A0PJR5; -.
DR   GeneID; 780842; -.
DR   KEGG; dre:780842; -.
DR   CTD; 79746; -.
DR   ZFIN; ZDB-GENE-061201-12; echdc3.
DR   eggNOG; KOG1682; Eukaryota.
DR   InParanoid; A0PJR5; -.
DR   OrthoDB; 804458at2759; -.
DR   PhylomeDB; A0PJR5; -.
DR   PRO; PR:A0PJR5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0016836; F:hydro-lyase activity; IBA:GO_Central.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.12.10; -; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR014748; Enoyl-CoA_hydra_C.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   2: Evidence at transcript level;
KW   Fatty acid metabolism; Lipid metabolism; Mitochondrion; Reference proteome;
KW   Transit peptide.
FT   TRANSIT         1..14
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           15..289
FT                   /note="Enoyl-CoA hydratase domain-containing protein 3,
FT                   mitochondrial"
FT                   /id="PRO_0000333218"
SQ   SEQUENCE   289 AA;  31439 MW;  1F1578F9EDCED2C8 CRC64;
     MLLRGFSELL KCRGVMMKMR MKMSGDSSSL TLTEQQGGIR RIILNNPRKR NALSLQMLES
     LRENILTDAD NPELHVIIIS AVGPVFSSGH DLQELSSAEG SDLPRRVFHS CSELMMLIQD
     LPVPVIAMVN GVATAAGCQL VASCDVAVAS EKSTFATPGV NVGLFCSTPA VAIGRTVPRK
     IAMQMLLTGR PLSAQQALQH GLLSAVFSEE RLEDETLAIA RRVCESSRPV VSLGKQIFNT
     QMSQSRDAAY STAGAAMLDN LRLRDGQEGI RAFLEKRKPV WSNTDDCIH