ID   ECHD3_RAT               Reviewed;         300 AA.
AC   Q3MIE0;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-OCT-2005, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Enoyl-CoA hydratase domain-containing protein 3, mitochondrial {ECO:0000305};
DE   Flags: Precursor;
GN   Name=Echdc3 {ECO:0000312|RGD:1589147};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May play a role in fatty acid biosynthesis and insulin
CC       sensitivity. {ECO:0000250|UniProtKB:Q96DC8}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000305}.
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DR   EMBL; BC101897; AAI01898.1; -; mRNA.
DR   RefSeq; NP_001094480.1; NM_001101010.1.
DR   AlphaFoldDB; Q3MIE0; -.
DR   SMR; Q3MIE0; -.
DR   STRING; 10116.ENSRNOP00000067768; -.
DR   iPTMnet; Q3MIE0; -.
DR   PhosphoSitePlus; Q3MIE0; -.
DR   PaxDb; Q3MIE0; -.
DR   PRIDE; Q3MIE0; -.
DR   GeneID; 684538; -.
DR   KEGG; rno:684538; -.
DR   CTD; 79746; -.
DR   RGD; 1589147; Echdc3.
DR   eggNOG; KOG1682; Eukaryota.
DR   InParanoid; Q3MIE0; -.
DR   OrthoDB; 804458at2759; -.
DR   PhylomeDB; Q3MIE0; -.
DR   PRO; PR:Q3MIE0; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR   GO; GO:0004300; F:enoyl-CoA hydratase activity; IMP:UniProtKB.
DR   GO; GO:0016836; F:hydro-lyase activity; IBA:GO_Central.
DR   GO; GO:0006631; P:fatty acid metabolic process; IMP:UniProtKB.
DR   GO; GO:1900078; P:positive regulation of cellular response to insulin stimulus; ISO:RGD.
DR   Gene3D; 1.10.12.10; -; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR014748; Enoyl-CoA_hydra_C.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   2: Evidence at transcript level;
KW   Fatty acid metabolism; Lipid metabolism; Mitochondrion; Reference proteome;
KW   Transit peptide.
FT   TRANSIT         1..66
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           67..300
FT                   /note="Enoyl-CoA hydratase domain-containing protein 3,
FT                   mitochondrial"
FT                   /id="PRO_0000333217"
FT   REGION          32..54
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         110
FT                   /note="N6-succinyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D7J9"
SQ   SEQUENCE   300 AA;  32385 MW;  4DD721F5B367FC44 CRC64;
     MALVAGLRAF GAKWPSWLRR SPWAPLSAGF CSPGSARPAG PESEPRLTST RQQDGIRNIV
     LSNPRRRNAL SLAMLKSLRS DILHEAESED LKVIIISAEG PVFSSGHDLK ELTGAQGRDY
     HTEVFQTCSE VMMLIRNHPV PIVAMVNGLA TAAGCQLVAS CDIAVASDKS SFATPGVNVG
     LFCSTPAVAL GRAVPRKVAL EMLFTGEPIS AQEALRHGLI SKVVPEEQLE EEATRIAKKI
     ASLSRSVVAL GKATFYKQLP QDLSTAYFLA SQAMVDNLTL KDGQEGIEAF IQKRRPVWSH