ID   ECHD3_XENLA             Reviewed;         294 AA.
AC   A9JS71;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Enoyl-CoA hydratase domain-containing protein 3, mitochondrial;
DE   Flags: Precursor;
GN   Name=echdc3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in fatty acid biosynthesis and insulin
CC       sensitivity. {ECO:0000250|UniProtKB:Q96DC8}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the enoyl-CoA hydratase/isomerase family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC155941; AAI55942.1; -; mRNA.
DR   RefSeq; NP_001106357.1; NM_001112886.1.
DR   AlphaFoldDB; A9JS71; -.
DR   SMR; A9JS71; -.
DR   MaxQB; A9JS71; -.
DR   GeneID; 100127325; -.
DR   KEGG; xla:100127325; -.
DR   CTD; 100127325; -.
DR   Xenbase; XB-GENE-1194020; echdc3.L.
DR   OMA; SCDMVVC; -.
DR   OrthoDB; 804458at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 100127325; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.12.10; -; 1.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR   InterPro; IPR014748; Enoyl-CoA_hydra_C.
DR   Pfam; PF00378; ECH_1; 1.
DR   SUPFAM; SSF52096; SSF52096; 1.
PE   2: Evidence at transcript level;
KW   Fatty acid metabolism; Lipid metabolism; Mitochondrion; Reference proteome;
KW   Transit peptide.
FT   TRANSIT         1..61
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           62..294
FT                   /note="Enoyl-CoA hydratase domain-containing protein 3,
FT                   mitochondrial"
FT                   /id="PRO_0000333219"
SQ   SEQUENCE   294 AA;  32189 MW;  0835BBDA6F18C771 CRC64;
     MSWLRSCGER TAPALRGTYR ILAGQSRFVN SSSHLQHTPL TVLQQEHGIR RIILNNPQQR
     NALSLPMIQS LQKDILHEAD DPNLRVIIIS AEGNVFSSGH NLKELTAEYG KDYHMEVFNT
     CAKLMTLFQT LPVPVIAEVN GLATAAGCQL VASCDIAVAS DKSRFATPGV NVGLFCSTPG
     VALGRAVPRK VALEMLFTGE PISAHDALLH GLVSKVVPEE NLKSETNRIA LKICQTSHSV
     VALGKSTFYR QMAKSLTDAY KLTSEVMVEN LAMKDGQEGL KSFIQKRKPV WTHS