ID   ECHMN_ECHLU             Reviewed;           8 AA.
AC   C0HJF1;
DT   13-NOV-2013, integrated into UniProtKB/Swiss-Prot.
DT   13-NOV-2013, sequence version 1.
DT   10-FEB-2021, entry version 12.
DE   RecName: Full=Echinometrin {ECO:0000303|PubMed:23948330};
OS   Echinometra lucunter (Rock-boring urchin).
OC   Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Echinozoa; Echinoidea;
OC   Euechinoidea; Echinacea; Camarodonta; Echinidea; Echinometridae;
OC   Echinometra.
OX   NCBI_TaxID=105361;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, TISSUE SPECIFICITY, MASS SPECTROMETRY, AND
RP   SYNTHESIS.
RC   TISSUE=Coelomic fluid {ECO:0000269|PubMed:23948330};
RX   PubMed=23948330; DOI=10.1016/j.peptides.2013.07.031;
RA   Sciani J.M., Sampaio M.C., Zychar B.C., de Camargo Goncalves L.R.,
RA   Giorgi R., de Oliveira Nogueira T., de Melo R.L.,
RA   de Fatima Pereira Teixeira C., Pimenta D.C.;
RT   "Echinometrin: A novel mast cell degranulating peptide from the coelomic
RT   liquid of Echinometra lucunter sea urchin.";
RL   Peptides 53:13-21(2014).
CC   -!- FUNCTION: Pro-inflammatory agent which mediates the degranulation of
CC       mast cells thus evoking an inflammatory response. In vivo, when
CC       injected into rats, diminishes the pain threshold. Induces dose-
CC       dependent paw edema in mice. {ECO:0000269|PubMed:23948330}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space
CC       {ECO:0000305|PubMed:23948330}.
CC   -!- TISSUE SPECIFICITY: Detected in the coelomic fluid.
CC       {ECO:0000269|PubMed:23948330}.
CC   -!- MASS SPECTROMETRY: Mass=1056.591; Mass_error=0.006;
CC       Method=Electrospray; Evidence={ECO:0000269|PubMed:23948330};
CC   -!- MISCELLANEOUS: May be produced from vitellogenin or creatine kinase by
CC       limited proteolysis. {ECO:0000303|PubMed:23948330}.
CC   -!- MISCELLANEOUS: Does not induce hemolysis in human erythrocytes and has
CC       no antibacterial properties. {ECO:0000269|PubMed:23948330}.
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DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-SubCell.
DR   GO; GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Mast cell degranulation; Secreted.
FT   PEPTIDE         1..8
FT                   /note="Echinometrin"
FT                   /evidence="ECO:0000269|PubMed:23948330"
FT                   /id="PRO_0000424422"
SQ   SEQUENCE   8 AA;  1057 MW;  1816D72697232407 CRC64;
     LRKLMLQR