ADR1_ARATH
ID ADR1_ARATH Reviewed; 787 AA.
AC Q9FW44;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2004, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Disease resistance protein ADR1;
DE AltName: Full=Activated disease resistance protein 1;
GN Name=ADR1; OrderedLocusNames=At1g33560; ORFNames=F10C21.19, T1E4.6;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND INDUCTION.
RX PubMed=12906111; DOI=10.1094/mpmi.2003.16.8.669;
RA Grant J.J., Chini A., Basu D., Loake G.J.;
RT "Targeted activation tagging of the Arabidopsis NBS-LRR gene, ADR1, conveys
RT resistance to virulent pathogens.";
RL Mol. Plant Microbe Interact. 16:669-680(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Disease resistance (R) protein that mediates resistance
CC against Hyaloperonospora parasitica in a salicylic acid-dependent
CC manner. Also mediates resistance against Erysiphe cichoracearum is both
CC salicylic acid-dependent and partially NPR1-dependent. Resistance
CC proteins guard the plant against pathogens that contain an appropriate
CC avirulence protein via an indirect interaction with this avirulence
CC protein. That triggers a defense system including the hypersensitive
CC response, which restricts the pathogen growth.
CC {ECO:0000269|PubMed:12906111}.
CC -!- INDUCTION: Accumulates in leaves 1.5 hours postinfiltration of
CC Pseudomonas syringae. {ECO:0000269|PubMed:12906111}.
CC -!- DOMAIN: The LRR repeats probably act as specificity determinant of
CC pathogen recognition. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG26078.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAG51211.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC -!- WEB RESOURCE: Name=NIB-LRRS; Note=Functional and comparative genomics
CC of disease resistance gene homologs;
CC URL="http://niblrrs.ucdavis.edu";
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DR EMBL; AJ581996; CAE46486.1; -; mRNA.
DR EMBL; AC051630; AAG51211.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC069299; AAG26078.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE31605.1; -; Genomic_DNA.
DR PIR; D86459; D86459.
DR RefSeq; NP_174620.2; NM_103079.4.
DR AlphaFoldDB; Q9FW44; -.
DR SMR; Q9FW44; -.
DR STRING; 3702.AT1G33560.1; -.
DR iPTMnet; Q9FW44; -.
DR PaxDb; Q9FW44; -.
DR PRIDE; Q9FW44; -.
DR ProteomicsDB; 244905; -.
DR EnsemblPlants; AT1G33560.1; AT1G33560.1; AT1G33560.
DR GeneID; 840250; -.
DR Gramene; AT1G33560.1; AT1G33560.1; AT1G33560.
DR KEGG; ath:AT1G33560; -.
DR Araport; AT1G33560; -.
DR TAIR; locus:2006932; AT1G33560.
DR eggNOG; ENOG502QU6E; Eukaryota.
DR HOGENOM; CLU_012216_1_0_1; -.
DR InParanoid; Q9FW44; -.
DR OMA; LPREWEK; -.
DR OrthoDB; 175097at2759; -.
DR PhylomeDB; Q9FW44; -.
DR PRO; PR:Q9FW44; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9FW44; baseline and differential.
DR Genevisible; Q9FW44; AT.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; TAS:TAIR.
DR GO; GO:0042742; P:defense response to bacterium; IGI:TAIR.
DR GO; GO:0009626; P:plant-type hypersensitive response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEP:TAIR.
DR GO; GO:0009414; P:response to water deprivation; IMP:TAIR.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 1.10.8.430; -; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008808; Powdery_mildew-R_dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR11017; PTHR11017; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF05659; RPW8; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51153; RPW8; 1.
PE 2: Evidence at transcript level;
KW ATP-binding; Coiled coil; Hypersensitive response; Leucine-rich repeat;
KW Nucleotide-binding; Plant defense; Reference proteome; Repeat.
FT CHAIN 1..787
FT /note="Disease resistance protein ADR1"
FT /id="PRO_0000212732"
FT DOMAIN 1..149
FT /note="RPW8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00495"
FT DOMAIN 247..414
FT /note="NB-ARC"
FT REPEAT 549..575
FT /note="LRR 1"
FT REPEAT 576..599
FT /note="LRR 2"
FT REPEAT 650..674
FT /note="LRR 3"
FT REPEAT 722..745
FT /note="LRR 4"
FT COILED 96..112
FT /evidence="ECO:0000255"
FT BINDING 193..200
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 787 AA; 90129 MW; DD13DC48D8071F59 CRC64;
MASFIDLFAG DITTQLLKLL ALVANTVYSC KGIAERLITM IRDVQPTIRE IQYSGAELSN
HHQTQLGVFY EILEKARKLC EKVLRCNRWN LKHVYHANKM KDLEKQISRF LNSQILLFVL
AEVCHLRVNG DRIERNMDRL LTERNDSLSF PETMMEIETV SDPEIQTVLE LGKKKVKEMM
FKFTDTHLFG ISGMSGSGKT TLAIELSKDD DVRGLFKNKV LFLTVSRSPN FENLESCIRE
FLYDGVHQRK LVILDDVWTR ESLDRLMSKI RGSTTLVVSR SKLADPRTTY NVELLKKDEA
MSLLCLCAFE QKSPPSPFNK YLVKQVVDEC KGLPLSLKVL GASLKNKPER YWEGVVKRLL
RGEAADETHE SRVFAHMEES LENLDPKIRD CFLDMGAFPE DKKIPLDLLT SVWVERHDID
EETAFSFVLR LADKNLLTIV NNPRFGDVHI GYYDVFVTQH DVLRDLALHM SNRVDVNRRE
RLLMPKTEPV LPREWEKNKD EPFDAKIVSL HTGEMDEMNW FDMDLPKAEV LILNFSSDNY
VLPPFIGKMS RLRVLVIINN GMSPARLHGF SIFANLAKLR SLWLKRVHVP ELTSCTIPLK
NLHKIHLIFC KVKNSFVQTS FDISKIFPSL SDLTIDHCDD LLELKSIFGI TSLNSLSITN
CPRILELPKN LSNVQSLERL RLYACPELIS LPVEVCELPC LKYVDISQCV SLVSLPEKFG
KLGSLEKIDM RECSLLGLPS SVAALVSLRH VICDEETSSM WEMVKKVVPE LCIEVAKKCF
TVDWLDD
