ID   ECL1_SCHPO              Reviewed;          80 AA.
AC   C6Y4D3;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Extender of the chronological lifespan protein 1;
GN   Name=ecl1; ORFNames=SPCC70.12c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION.
RX   PubMed=18422613; DOI=10.1111/j.1567-1364.2008.00379.x;
RA   Ohtsuka H., Mita S., Ogawa Y., Azuma K., Ito H., Aiba H.;
RT   "A novel gene, ecl1(+), extends the chronological lifespan in fission
RT   yeast.";
RL   FEMS Yeast Res. 8:520-530(2008).
CC   -!- FUNCTION: Involved in chronological cell aging. Extends cell viability
CC       after entry into the stationary phase probably through affecting the
CC       Pka1-dependent pathway negatively. {ECO:0000269|PubMed:18422613}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18422613}.
CC   -!- INDUCTION: Up-regulated transiently when the growth phase was changed
CC       from the log phase to the stationary phase.
CC       {ECO:0000269|PubMed:18422613}.
CC   -!- SIMILARITY: Belongs to the ecl1 family. {ECO:0000305}.
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DR   EMBL; CU329672; CBA11520.1; -; Genomic_DNA.
DR   RefSeq; XP_002788952.1; XM_002788906.2.
DR   AlphaFoldDB; C6Y4D3; -.
DR   BioGRID; 1028327; 10.
DR   STRING; 4896.SPCC70.12c.1; -.
DR   iPTMnet; C6Y4D3; -.
DR   PaxDb; C6Y4D3; -.
DR   PRIDE; C6Y4D3; -.
DR   EnsemblFungi; SPCC70.12c.1; SPCC70.12c.1:pep; SPCC70.12c.
DR   PomBase; SPCC70.12c; ecl1.
DR   VEuPathDB; FungiDB:SPCC70.12c; -.
DR   HOGENOM; CLU_2528757_0_0_1; -.
DR   PRO; PR:C6Y4D3; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0005634; C:nucleus; IDA:PomBase.
DR   GO; GO:0008270; F:zinc ion binding; EXP:PomBase.
DR   GO; GO:0010106; P:cellular response to iron ion starvation; IC:GOC-OWL.
DR   GO; GO:0000747; P:conjugation with cellular fusion; IMP:PomBase.
DR   InterPro; IPR024368; Ecl1/2/3.
DR   Pfam; PF12855; Ecl1; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..80
FT                   /note="Extender of the chronological lifespan protein 1"
FT                   /id="PRO_0000389114"
SQ   SEQUENCE   80 AA;  8973 MW;  282E5448CF85F8F4 CRC64;
     MDLDFCTVCG ATTQDGSLYC SSECHLLDFT KLDTQTTSNI SVSSEYQFLV SEHLAHFHRK
     SMTSADFPTP RFSAYTKLHA