ECLH_BOMMO
ID ECLH_BOMMO Reviewed; 88 AA.
AC P25331;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 2.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Eclosion hormone;
DE AltName: Full=EH;
DE AltName: Full=Ecdysis activator;
DE Flags: Precursor;
OS Bombyx mori (Silk moth).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC Bombycidae; Bombycinae; Bombyx.
OX NCBI_TaxID=7091;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=1370883; DOI=10.1016/0006-291x(92)91762-f;
RA Kamito T., Tanaka H., Sato B., Nagasawa H., Suzuki A.;
RT "Nucleotide sequence of cDNA for the eclosion hormone of the silkworm,
RT Bombyx mori, and the expression in a brain.";
RL Biochem. Biophys. Res. Commun. 182:514-519(1992).
RN [2]
RP PROTEIN SEQUENCE OF 27-87.
RA Kono T., Nagasawa H., Isogai A., Fugo H., Suzuki A.;
RT "Amino acid sequence of eclosion hormone of the silkworm, Bombyx mori.";
RL Agric. Biol. Chem. 51:2307-2308(1987).
CC -!- FUNCTION: Neuropeptide that triggers the performance of ecdysis
CC behaviors at the end of a molt. It triggers adult behavior patterns:
CC larval, pupal and adult ecdysis, and plasticization during the molt.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the insect eclosion hormone family.
CC {ECO:0000305}.
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DR EMBL; D10135; BAA01012.1; -; mRNA.
DR PIR; JS0644; JS0644.
DR RefSeq; NP_001037307.1; NM_001043842.1.
DR RefSeq; XP_012553269.1; XM_012697815.1.
DR RefSeq; XP_012553270.1; XM_012697816.1.
DR AlphaFoldDB; P25331; -.
DR SMR; P25331; -.
DR STRING; 7091.BGIBMGA006291-TA; -.
DR EnsemblMetazoa; BGIBMGA006291-RA; BGIBMGA006291-TA; BGIBMGA006291.
DR GeneID; 692740; -.
DR KEGG; bmor:692740; -.
DR CTD; 103935; -.
DR eggNOG; ENOG502S767; Eukaryota.
DR HOGENOM; CLU_175797_0_0_1; -.
DR InParanoid; P25331; -.
DR OMA; GQKCADS; -.
DR OrthoDB; 1621219at2759; -.
DR Proteomes; UP000005204; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008255; F:ecdysis-triggering hormone activity; IEA:InterPro.
DR GO; GO:0018990; P:ecdysis, chitin-based cuticle; IEA:InterPro.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR006825; Eclosion.
DR Pfam; PF04736; Eclosion; 1.
DR PIRSF; PIRSF001859; Eclosion; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Hormone; Neuropeptide;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000269|Ref.2"
FT CHAIN 27..88
FT /note="Eclosion hormone"
FT /id="PRO_0000021143"
FT DISULFID 40..64
FT /evidence="ECO:0000250"
FT DISULFID 44..60
FT /evidence="ECO:0000250"
FT DISULFID 47..75
FT /evidence="ECO:0000250"
FT CONFLICT 31
FT /note="A -> S (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 33
FT /note="S -> G (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 46
FT /note="Q -> E (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 67..68
FT /note="AR -> FK (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 70..71
FT /note="KD -> DL (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 88 AA; 9505 MW; 429DDC0ADDAAD852 CRC64;
MANKLTAVIV VALAVAFMVN LDYANCSPAI ASSYDAMEIC IENCAQCKKM FGPWFEGSLC
AESCIKARGK DIPECESFAS ISPFLNKL
