ECM11_YEAST
ID ECM11_YEAST Reviewed; 302 AA.
AC Q04110; D6VT71;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Protein ECM11;
DE AltName: Full=Extracellular mutant protein 11;
GN Name=ECM11; OrderedLocusNames=YDR446W; ORFNames=D9461.31;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP IDENTIFICATION.
RX PubMed=9335584; DOI=10.1093/genetics/147.2.435;
RA Lussier M., White A.-M., Sheraton J., di Paolo T., Treadwell J.,
RA Southard S.B., Horenstein C.I., Chen-Weiner J., Ram A.F.J., Kapteyn J.C.,
RA Roemer T.W., Vo D.H., Bondoc D.C., Hall J., Zhong W.-W., Sdicu A.-M.,
RA Davies J., Klis F.M., Robbins P.W., Bussey H.;
RT "Large scale identification of genes involved in cell surface biosynthesis
RT and architecture in Saccharomyces cerevisiae.";
RL Genetics 147:435-450(1997).
RN [4]
RP INTERACTION WITH CDC6.
RX PubMed=10653153; DOI=10.1007/s004240000103;
RA Zavec P.B., Comino A., Watt P., Komel R.;
RT "Interaction trap experiment with CDC6.";
RL Pflugers Arch. 439:R94-R96(2000).
RN [5]
RP SUBCELLULAR LOCATION.
RX PubMed=11678331; DOI=10.1007/s004240100016;
RA Comino A., Mancek M., Komel R.;
RT "Ecm11 is located in the cell nucleus throughout mitosis.";
RL Pflugers Arch. 442:R179-R181(2001).
CC -!- FUNCTION: May be involved in cell wall organization and biogenesis.
CC -!- SUBUNIT: Interacts with CDC6. {ECO:0000269|PubMed:10653153}.
CC -!- INTERACTION:
CC Q04110; Q06201: GMC2; NbExp=4; IntAct=EBI-37150, EBI-3786338;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11678331}.
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DR EMBL; U33007; AAB64870.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA12281.1; -; Genomic_DNA.
DR PIR; S69725; S69725.
DR RefSeq; NP_010734.1; NM_001180754.1.
DR AlphaFoldDB; Q04110; -.
DR SMR; Q04110; -.
DR BioGRID; 32501; 46.
DR ComplexPortal; CPX-1387; Synaptonemal complex.
DR ComplexPortal; CPX-1407; ECM11-GMC2 synaptonemal assembly activation factor complex.
DR DIP; DIP-2060N; -.
DR IntAct; Q04110; 5.
DR STRING; 4932.YDR446W; -.
DR PaxDb; Q04110; -.
DR PRIDE; Q04110; -.
DR EnsemblFungi; YDR446W_mRNA; YDR446W; YDR446W.
DR GeneID; 852057; -.
DR KEGG; sce:YDR446W; -.
DR SGD; S000002854; ECM11.
DR VEuPathDB; FungiDB:YDR446W; -.
DR eggNOG; ENOG502S4IU; Eukaryota.
DR HOGENOM; CLU_921822_0_0_1; -.
DR InParanoid; Q04110; -.
DR OMA; TEHTAFQ; -.
DR BioCyc; YEAST:G3O-29977-MON; -.
DR PRO; PR:Q04110; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; Q04110; protein.
DR GO; GO:0000794; C:condensed nuclear chromosome; IDA:ComplexPortal.
DR GO; GO:0005634; C:nucleus; IDA:SGD.
DR GO; GO:0000795; C:synaptonemal complex; IDA:SGD.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; IC:ComplexPortal.
DR GO; GO:0035825; P:homologous recombination; IC:ComplexPortal.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IMP:SGD.
DR GO; GO:1990414; P:replication-born double-strand break repair via sister chromatid exchange; IMP:SGD.
DR GO; GO:0007130; P:synaptonemal complex assembly; IMP:ComplexPortal.
DR GO; GO:0070193; P:synaptonemal complex organization; IMP:SGD.
DR InterPro; IPR029178; Ecm11_C.
DR Pfam; PF15463; ECM11; 1.
PE 1: Evidence at protein level;
KW Cell wall biogenesis/degradation; Nucleus; Reference proteome.
FT CHAIN 1..302
FT /note="Protein ECM11"
FT /id="PRO_0000086912"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..65
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 302 AA; 34113 MW; CB6890F4EE069232 CRC64;
MTVIKTEPTT EVTLYSPPSK ESLSKDDAHR KKQNNKPPSS INSRSGPNKH KLAAKAPEKK
INNTDKQDLS AFLLNPSLIV KPSESKKKEN IVAYNDTPGI KTEHTAFQPL TPISKKRALK
EKAASEKCDS FDLSRDEKPY IQKKSKTLSS VTEINSSEYK LSLNGENTSS PAKEKSQEPI
ENPGSYQKTR NYLFEKPDPL DTCLQDYSSM LPSNVAEEDQ EYFISVADST LEEWTNKGQE
IIDQQFQLYQ EIIKKRIELS YKFKGIISVI NDRADALEEQ GQQLEGKIKK VKTLANEILN
II
