ADR1_CANAL
ID ADR1_CANAL Reviewed; 1418 AA.
AC Q5AF56; A0A1D8PLK2;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2017, sequence version 2.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=Transcriptional regulator ADR1;
GN Name=ADR1; OrderedLocusNames=CAALFM_C402500CA;
GN ORFNames=CaO19.10266, CaO19.2752;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=12773383; DOI=10.1093/emboj/cdg256;
RA Uhl M.A., Biery M., Craig N., Johnson A.D.;
RT "Haploinsufficiency-based large-scale forward genetic analysis of
RT filamentous growth in the diploid human fungal pathogen C.albicans.";
RL EMBO J. 22:2668-2678(2003).
RN [5]
RP IDENTIFICATION.
RX PubMed=19700635; DOI=10.1128/ec.00206-09;
RA Ramirez M.A., Lorenz M.C.;
RT "The transcription factor homolog CTF1 regulates {beta}-oxidation in
RT Candida albicans.";
RL Eukaryot. Cell 8:1604-1614(2009).
RN [6]
RP INDUCTION.
RX PubMed=22265407; DOI=10.1016/j.cell.2011.10.048;
RA Nobile C.J., Fox E.P., Nett J.E., Sorrells T.R., Mitrovich Q.M.,
RA Hernday A.D., Tuch B.B., Andes D.R., Johnson A.D.;
RT "A recently evolved transcriptional network controls biofilm development in
RT Candida albicans.";
RL Cell 148:126-138(2012).
CC -!- FUNCTION: Transcription factor involved in the regulation of hyphal
CC growth. {ECO:0000269|PubMed:12773383}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- INDUCTION: Expression is increased in biofilm.
CC {ECO:0000269|PubMed:22265407}.
CC -!- DISRUPTION PHENOTYPE: Affects filamentous growth.
CC {ECO:0000269|PubMed:12773383}.
CC -!- MISCELLANEOUS: Targets a different set of genes than S.cerevisiae ADR1.
CC {ECO:0000305|PubMed:12773383}.
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DR EMBL; CP017626; AOW29019.1; -; Genomic_DNA.
DR RefSeq; XP_720502.2; XM_715409.2.
DR AlphaFoldDB; Q5AF56; -.
DR SMR; Q5AF56; -.
DR BioGRID; 1220960; 1.
DR STRING; 237561.Q5AF56; -.
DR PRIDE; Q5AF56; -.
DR GeneID; 3637866; -.
DR KEGG; cal:CAALFM_C402500CA; -.
DR CGD; CAL0000189036; ADR1.
DR VEuPathDB; FungiDB:C4_02500C_A; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_007571_0_0_1; -.
DR InParanoid; Q5AF56; -.
DR OrthoDB; 455084at2759; -.
DR PRO; PR:Q5AF56; -.
DR Proteomes; UP000000559; Chromosome 4.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 2: Evidence at transcript level;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..1418
FT /note="Transcriptional regulator ADR1"
FT /id="PRO_0000426051"
FT ZN_FING 117..139
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 145..168
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 34..96
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 403..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 454..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1132..1167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1338..1362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..208
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 209..231
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..285
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1418 AA; 160414 MW; 3B44866A0B841777 CRC64;
MISPTHQSQY LNYFVNPVLM TESGDIIDSV TGTTTTTANM SNTTIDAPTP ASTTKNYKHK
KQNTNTGTSM SPSNSINSTN NNAAAAAATT TTSKKSKDIP LELTAFGTTP SGKPRLFVCQ
VCTRAFARLE HLRRHERSHT KEKPFSCGVC QRKFSRRDLL LRHAQKLHAG CTDAITRLRR
KSIKKSQDGD DDDDDDDDDE EMANSEDEND HDESGNASTK NGKKDKKDPP PEFNLNLFNS
KQKPTKANTT KSKVAKLSTT TSRKNSTNPT RKNSSSLHKQ VLDQRQKAAV NTKIVSSTKI
VSGTNSGVSI TPTRSRRGAS FSAQSGANYA INIPEFNDIY PQSDNVEFST PQFLPSSLDN
EMTWLNNIPN IPGLSDSVSA ANLMRQNSIT NSADHVTPPV NVSQHGSFSH QSTFSATDMG
QTRSESVNSL NTPFDGSYMM PTVTISNQEI QNGVAAHHHH QQQQQHQQHN HQHQPNQSSL
GLSRNDMLSE DHYGYSFYDI PENILNFPMD SISTTSNAMS SGPIQNFKPL SPITQEIEHE
ITPRIDGRIG DFQNNNNTND NPIHQNINYD LNFLHTIDDI GQDVISKFMP GGYSFYGDNN
VSATSSANDY NSPNNIVSPS QQNNQFALHN QSSHPSGASP HLNQAMMNKM RLHNYSSNKL
FTNHIRHMIN KALGKYPISG IMTPTIPSNE KLEFYLSVFI QSFLAHLPFI HPSKLNEYEI
MAMTGNEDIN NESARVCLPL LTATMGALLA NNKNDAEHLY EASRRTIHIY LESRKTNSTN
DKNYKNGKDK SSSGNPLWLL QSLMLSVLYG LFSDNENNVY IVIRQLNALN SLVKTSIKNK
GPIFFSNNGE DEELYNKLNS HDNGTSLFSN NLNDEMRYKN NINMQSQTRI VFIIYRLTNF
LLMMYNVPLT FSINDINQLA VTSKDEETLW NFKNYQEFQE FSHKNNKTLD DYLNHKNEPI
IFRELLLTVI KFGISDSNIS PEIEKKVTHQ LQNLCKYGFN CLVHGIYEIK QYQEMKEVDT
FKVLDYLTKF YPTNDGLGFN CFRLPANKDL EKIDYALLVD FTKISSIIDL KLLKEQSWLK
NYQDLTQNYH RLLDAHSTGN PLNSINDYDY LKLADCCISV LKLILFKVED SNSNSRNRSK
NDPTNEINNK LNNNNNNNND MNNNNSNGDQ LISAFDTDFG YLNMDNNGYA KKEEFSRFTD
DELRYDKENT MSYFDKHIKL DIFEEVEKSS NLIQAQMLFH AFSVLSIFSV YVMRKNDNNS
SPFANTDLIF ELNHRYSMVL RLLERLETFL KLRYQTSAGG GGGGVNNNNN NALSIKLEQE
FTNLYLYNGN VLSSDHNTNT NTTNTITTTT TTDNGTKQNQ HHSQDFGLEK TLYILKMGEN
VLNYIYDLNL KVCVFKKLGD SLSEIRKYLI DNESTLNG
