ECM23_YEAST
ID ECM23_YEAST Reviewed; 187 AA.
AC Q02710; D6W3Z1;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Protein ECM23;
DE AltName: Full=Extracellular mutant protein 23;
DE AltName: Full=SRD1 homolog 2;
GN Name=ECM23; Synonyms=SRD2; OrderedLocusNames=YPL021W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169875;
RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA Vo D.H., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL Nature 387:103-105(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RA Marsischky G., Rolfs A., Richardson A., Kane M., Baqui M., Taycher E.,
RA Hu Y., Vannberg F., Weger J., Kramer J., Moreira D., Kelley F., Zuo D.,
RA Raphael J., Hogle C., Jepson D., Williamson J., Camargo A., Gonzaga L.,
RA Vasconcelos A.T., Simpson A.J.G., Kolodner R., Harlow E., LaBaer J.;
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP IDENTIFICATION.
RX PubMed=9335584; DOI=10.1093/genetics/147.2.435;
RA Lussier M., White A.-M., Sheraton J., di Paolo T., Treadwell J.,
RA Southard S.B., Horenstein C.I., Chen-Weiner J., Ram A.F.J., Kapteyn J.C.,
RA Roemer T.W., Vo D.H., Bondoc D.C., Hall J., Zhong W.-W., Sdicu A.-M.,
RA Davies J., Klis F.M., Robbins P.W., Bussey H.;
RT "Large scale identification of genes involved in cell surface biosynthesis
RT and architecture in Saccharomyces cerevisiae.";
RL Genetics 147:435-450(1997).
RN [5]
RP FUNCTION.
RX PubMed=11889490; DOI=10.1007/s00203-002-0400-z;
RA Canizares J.V., Pallotti C., Sainz-Pardo I., Iranzo M., Mormeneo S.;
RT "The SRD2 gene is involved in Saccharomyces cerevisiae morphogenesis.";
RL Arch. Microbiol. 177:352-357(2002).
RN [6]
RP INDUCTION.
RX PubMed=17101777; DOI=10.1128/mcb.00439-06;
RA Lahav R., Gammie A., Tavazoie S., Rose M.D.;
RT "Role of transcription factor Kar4 in regulating downstream events in the
RT Saccharomyces cerevisiae pheromone response pathway.";
RL Mol. Cell. Biol. 27:818-829(2007).
CC -!- FUNCTION: Involved in morphogenesis. May be involved in cell wall
CC organization and biogenesis. {ECO:0000269|PubMed:11889490}.
CC -!- INDUCTION: Expression is regulated by the KAR4 transcription factor and
CC reduced after pheromone induction. {ECO:0000269|PubMed:17101777}.
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DR EMBL; U36624; AAB68166.1; -; Genomic_DNA.
DR EMBL; AY558439; AAS56765.1; -; Genomic_DNA.
DR EMBL; BK006949; DAA11407.1; -; Genomic_DNA.
DR PIR; S63461; S63461.
DR RefSeq; NP_015304.1; NM_001183835.1.
DR AlphaFoldDB; Q02710; -.
DR SMR; Q02710; -.
DR BioGRID; 36156; 90.
DR STRING; 4932.YPL021W; -.
DR PaxDb; Q02710; -.
DR PRIDE; Q02710; -.
DR EnsemblFungi; YPL021W_mRNA; YPL021W; YPL021W.
DR GeneID; 856086; -.
DR KEGG; sce:YPL021W; -.
DR SGD; S000005942; ECM23.
DR VEuPathDB; FungiDB:YPL021W; -.
DR eggNOG; KOG1601; Eukaryota.
DR GeneTree; ENSGT00940000181677; -.
DR HOGENOM; CLU_1533773_0_0_1; -.
DR InParanoid; Q02710; -.
DR OMA; VELCSRC; -.
DR BioCyc; YEAST:G3O-33939-MON; -.
DR PRO; PR:Q02710; -.
DR Proteomes; UP000002311; Chromosome XVI.
DR RNAct; Q02710; protein.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:SGD.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR GO; GO:0007124; P:pseudohyphal growth; IMP:SGD.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR Pfam; PF00320; GATA; 1.
DR SMART; SM00401; ZnF_GATA; 1.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 1.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
PE 2: Evidence at transcript level;
KW Cell wall biogenesis/degradation; Metal-binding; Reference proteome; Zinc;
KW Zinc-finger.
FT CHAIN 1..187
FT /note="Protein ECM23"
FT /id="PRO_0000083483"
FT ZN_FING 126..180
FT /note="GATA-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT REGION 106..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 187 AA; 20614 MW; 8682AFC484011926 CRC64;
MLYNKEQGTS GASSSGRRTK FHFDRFVQMV LFIAANPNYC CSVASIPKSG VTPDLKRADI
LEQKIKSLNS ALSPKLKEES RLGGPLHNPS ILPAPSFSSL PISSNGKKSL AGYRPKSRKK
QTILPNGQPK ECATCGDTWT SQWRSGPNGN VELCSRCGIA YRKKMEKKIR SQQSSDDGTK
NFIFKNK
