ECMA_DICDI
ID ECMA_DICDI Reviewed; 1710 AA.
AC Q54YG2;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 73.
DE RecName: Full=Extracellular matrix protein A;
DE AltName: Full=Extracellular matrix protein ST430;
DE Flags: Precursor;
GN Name=ecmA; Synonyms=Dd63; ORFNames=DDB_G0277853;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP INDUCTION BY DIF.
RX PubMed=17177855; DOI=10.1111/j.1432-0436.2006.00085.x;
RA Rai M., Xiong Y., Singleton C.K.;
RT "Disruption of the ifkA and ifkB genes results in altered cell adhesion,
RT morphological defects and a propensity to form pre-stalk O cells during
RT development of Dictyostelium.";
RL Differentiation 74:583-595(2006).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- INDUCTION: Induced by the putative stalk-specific morphogen DIF
CC (differentiation inducing factor). {ECO:0000269|PubMed:17177855}.
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DR EMBL; AAFI02000023; EAL68099.1; -; Genomic_DNA.
DR RefSeq; XP_642240.1; XM_637148.1.
DR AlphaFoldDB; Q54YG2; -.
DR STRING; 44689.DDB0220137; -.
DR PaxDb; Q54YG2; -.
DR PRIDE; Q54YG2; -.
DR EnsemblProtists; EAL68099; EAL68099; DDB_G0277853.
DR GeneID; 8621449; -.
DR KEGG; ddi:DDB_G0277853; -.
DR dictyBase; DDB_G0277853; ecmA.
DR eggNOG; ENOG502RSRD; Eukaryota.
DR HOGENOM; CLU_240605_0_0_1; -.
DR InParanoid; Q54YG2; -.
DR OMA; NTCHCAD; -.
DR PhylomeDB; Q54YG2; -.
DR PRO; PR:Q54YG2; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0031012; C:extracellular matrix; HDA:dictyBase.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; TAS:dictyBase.
DR GO; GO:0031154; P:culmination involved in sorocarp development; IEP:dictyBase.
DR GO; GO:0030198; P:extracellular matrix organization; TAS:dictyBase.
DR GO; GO:1902168; P:response to catechin; IDA:dictyBase.
DR InterPro; IPR001673; S_mold_repeat.
DR Pfam; PF00526; Dicty_CTDC; 60.
PE 2: Evidence at transcript level;
KW Glycoprotein; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..1710
FT /note="Extracellular matrix protein A"
FT /id="PRO_0000384442"
FT REPEAT 43..70
FT /note="Cys-rich CT 1"
FT REPEAT 71..94
FT /note="Cys-rich CT 2"
FT REPEAT 95..117
FT /note="Cys-rich CT 3"
FT REPEAT 118..141
FT /note="Cys-rich CT 4"
FT REPEAT 142..165
FT /note="Cys-rich CT 5"
FT REPEAT 166..189
FT /note="Cys-rich CT 6"
FT REPEAT 190..213
FT /note="Cys-rich CT 7"
FT REPEAT 214..237
FT /note="Cys-rich CT 8"
FT REPEAT 238..261
FT /note="Cys-rich CT 9"
FT REPEAT 262..285
FT /note="Cys-rich CT 10"
FT REPEAT 286..309
FT /note="Cys-rich CT 11"
FT REPEAT 310..333
FT /note="Cys-rich CT 12"
FT REPEAT 334..357
FT /note="Cys-rich CT 13"
FT REPEAT 358..381
FT /note="Cys-rich CT 14"
FT REPEAT 382..405
FT /note="Cys-rich CT 15"
FT REPEAT 406..429
FT /note="Cys-rich CT 16"
FT REPEAT 430..453
FT /note="Cys-rich CT 17"
FT REPEAT 454..477
FT /note="Cys-rich CT 18"
FT REPEAT 478..501
FT /note="Cys-rich CT 19"
FT REPEAT 502..525
FT /note="Cys-rich CT 20"
FT REPEAT 526..549
FT /note="Cys-rich CT 21"
FT REPEAT 550..573
FT /note="Cys-rich CT 22"
FT REPEAT 574..597
FT /note="Cys-rich CT 23"
FT REPEAT 598..621
FT /note="Cys-rich CT 24"
FT REPEAT 622..645
FT /note="Cys-rich CT 25"
FT REPEAT 646..669
FT /note="Cys-rich CT 26"
FT REPEAT 670..693
FT /note="Cys-rich CT 27"
FT REPEAT 694..717
FT /note="Cys-rich CT 28"
FT REPEAT 718..741
FT /note="Cys-rich CT 29"
FT REPEAT 742..765
FT /note="Cys-rich CT 30"
FT REPEAT 766..789
FT /note="Cys-rich CT 31"
FT REPEAT 790..813
FT /note="Cys-rich CT 32"
FT REPEAT 814..837
FT /note="Cys-rich CT 33"
FT REPEAT 838..861
FT /note="Cys-rich CT 34"
FT REPEAT 862..885
FT /note="Cys-rich CT 35"
FT REPEAT 886..909
FT /note="Cys-rich CT 36"
FT REPEAT 910..933
FT /note="Cys-rich CT 37"
FT REPEAT 934..957
FT /note="Cys-rich CT 38"
FT REPEAT 958..981
FT /note="Cys-rich CT 39"
FT REPEAT 982..1005
FT /note="Cys-rich CT 40"
FT REPEAT 1006..1029
FT /note="Cys-rich CT 41"
FT REPEAT 1030..1053
FT /note="Cys-rich CT 42"
FT REPEAT 1054..1077
FT /note="Cys-rich CT 43"
FT REPEAT 1078..1101
FT /note="Cys-rich CT 44"
FT REPEAT 1102..1125
FT /note="Cys-rich CT 45"
FT REPEAT 1126..1149
FT /note="Cys-rich CT 46"
FT REPEAT 1150..1173
FT /note="Cys-rich CT 47"
FT REPEAT 1174..1197
FT /note="Cys-rich CT 48"
FT REPEAT 1198..1221
FT /note="Cys-rich CT 49"
FT REPEAT 1222..1245
FT /note="Cys-rich CT 50"
FT REPEAT 1246..1269
FT /note="Cys-rich CT 51"
FT REPEAT 1270..1293
FT /note="Cys-rich CT 52"
FT REPEAT 1294..1317
FT /note="Cys-rich CT 53"
FT REPEAT 1318..1341
FT /note="Cys-rich CT 54"
FT REPEAT 1342..1365
FT /note="Cys-rich CT 55"
FT REPEAT 1366..1389
FT /note="Cys-rich CT 56"
FT REPEAT 1390..1413
FT /note="Cys-rich CT 57"
FT REPEAT 1414..1437
FT /note="Cys-rich CT 58"
FT REPEAT 1438..1461
FT /note="Cys-rich CT 59"
FT REPEAT 1462..1485
FT /note="Cys-rich CT 60"
FT REPEAT 1486..1509
FT /note="Cys-rich CT 61"
FT REPEAT 1511..1534
FT /note="Cys-rich CT 62"
FT REPEAT 1558..1581
FT /note="Cys-rich CT 63"
FT REPEAT 1582..1606
FT /note="Cys-rich CT 64"
FT REPEAT 1608..1632
FT /note="Cys-rich CT 65"
FT REPEAT 1658..1682
FT /note="Cys-rich CT 66"
FT CARBOHYD 150
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 151
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 270
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 271
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 415
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 535
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 655
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 751
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 871
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 894
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 895
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1015
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1110
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1183
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1255
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1351
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1530
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1624
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1710 AA; 177830 MW; 008C47B85EFDD7D2 CRC64;
MKISIFILLL FISSMVIISV NAETETIQTN TACDCDDDCD DGNRWSTDMC SAGLLFGKYC
THTQICCDDE NACTIDSCSK TSGCVHTPIN VDDKNPCTID SCIKGFISHT QISCDDKNAC
TIDSCDCSSG CQNKPMSCDD NNPCTVDSCN NSTGCRNTPI SVDDNNPCTI DSCSKSTGVV
HIPINVDDLN PCTIDACTKE GGVTHTPVNV DDNNKCTTDS CSLFTGITHT EICCDDNNAC
TDDSCSPSTG CVNTPISCDD KNPCTVDSCN NSTGCCYTPI NVDDNNPCTI DACTKSTGVT
HTPINVDDNN QCTTDSCTKE GGVTHTPVNT DDNNPCTVDS CSPFTGVSHT PINVDDNNKC
TIDACTKEGG VTHTPVNTDD NNACTLDSCS PLTGVTHTPI NCDDKKACTV DSCSNSTGCV
NTPISCDDNN PCTVDTCDDS TGCCNTPINV DDNNPCTVDA CTKSTGVTHT PVNVDDNNKC
TIDACTKEGG VTHTPVNTDD NNACTLDNCS PLTGVTHTPI NCDDKKACTV DSCSNSTGCV
NTPISCDDNN PCTVDSCDDI TGCCNTPINV DDNNPCTVDA CTKSTGVTHT PVNVDDNNKC
TIDACTKEGG VTHTPVNTDD NNACTLDSCS PSTGVSHTPI NCDDSNPCTV DSCSNSTGCV
NTPVNVDDNN PCTVDACTKS TGVTHTPVNV DDNNKCTIDA CTKEGGVTHT PVNTDDNNAC
TIDSCSPSTG ISHTPINCDD KKACTVDSCS NSTGCVNTPI SCDDNNPCTV DSCDDLTGCC
NTPINVDDNN PCTIDACTKS TGVTHTPVNV DDNNKCTIDT CTKEGGVTHT PVNTDDNNAC
TLDSCSPSTG VSHTPINCDD NNKCTVDSCS NSTGCVNTPI NCDDSNPCTV DSCNNSTGCV
NTPVNVDDNN PCTVDACTKS TGVTHTPVNV DDNNKCTIDA CTKEGGVTHT PVNTDDNNAC
TIDACTKEGG VTHTPVNTDD NNACTLDSCS PSTGVSHTPI NCDDSNPCTV DSCSNSTGCC
NTPINVDDNN PCTVDSCTKP TGVTHTPVNV DDNNKCTIDA CTKEGGVTHT PVNTDDNNAC
TLDSCSPSTG ISHAPINCDD SNPCTIDSCN NSTGCCNTPI NVDDNNPCTV DSCTKSGGVT
HTPVNVDDNN KCTTDACTKE GGVTHTPISC DDNNACTIDS CSNSTGCVNT PISCDDRNPC
TVDTCTKEKG CQHSPIDTDD SNKCTIDACS STTGVTHTSI NCDDNNACTF DSCSNSTGCV
STPISCDDKN PCTLDSCDKK TGCCNTPINV DDNDKCTTDS CTKEGGVTHT PISCDDNNAC
TTDSCSKSTG CVNKPISCDD SNPCTVDSCS NSTGCCNTPI NVDDNNPCTT DSCTKSGGVT
HTPVNVDDNN KCTTDSCTKE GGITHTPISC DDNNPCTLDS CSPTTGCVNK PMNVDDNDAC
TTDTCNKDGT ITHTPINTDD NNKCTLDACS PKTGVTHTPI NCDDGNKCTI NSCSPSVGCI
STPVSCPKPK DKCSISQCDS AKGCIEVPMN CTSDKCNEAS CCDGVCTSKP ISCPKPKNKC
QVAKCDLIKG CTVSNVVCDD GNACTEDSCC SDTGKCQFEP IKLPKNKNKC IISKCDPIKG
TITNSTVNCE CDDLCNIGEC CEDTGKCNYR QKDCDDNNPK TADSCDSKTG KCINKPYNVI
TSGSNLISGL IGGLIGGGTG GKGDCKTCKN
