ID   ECOT1_LEIBR             Reviewed;         146 AA.
AC   A4H804;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Ecotin-like protein 1;
DE   AltName: Full=Inhibitor of serine peptidase 1;
DE            Short=LbISP1;
GN   Name=ISP1; ORFNames=LbrM15_V2.0340, LbrM_15_0340;
OS   Leishmania braziliensis.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC   Leishmania braziliensis species complex.
OX   NCBI_TaxID=5660;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904;
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.-A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Sqaures R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
CC   -!- SIMILARITY: Belongs to the protease inhibitor I11 (ecotin) family.
CC       {ECO:0000305}.
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DR   EMBL; FR798989; CAM42051.1; -; Genomic_DNA.
DR   RefSeq; XP_001563483.1; XM_001563433.1.
DR   AlphaFoldDB; A4H804; -.
DR   SMR; A4H804; -.
DR   GeneID; 5414000; -.
DR   KEGG; lbz:LBRM_15_0340; -.
DR   VEuPathDB; TriTrypDB:LbrM.15.0340; -.
DR   VEuPathDB; TriTrypDB:LBRM2903_150008600; -.
DR   InParanoid; A4H804; -.
DR   OMA; NDAANHQ; -.
DR   Proteomes; UP000007258; Chromosome 15.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   InterPro; IPR036198; Ecotin_sf.
DR   InterPro; IPR005658; Prot_inh_ecotin.
DR   PANTHER; PTHR35890; PTHR35890; 1.
DR   Pfam; PF03974; Ecotin; 1.
DR   SUPFAM; SSF49772; SSF49772; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..146
FT                   /note="Ecotin-like protein 1"
FT                   /id="PRO_0000291590"
SQ   SEQUENCE   146 AA;  16495 MW;  A3081D2CB1DE0618 CRC64;
     MSCCKMEAPY PHAESDEKRI VFALDPKGDD AERDQYRLQL IPGRVLEMSR NDAANHQTLS
     GSIEQHTVEG WGAPFFHVKL AKEAAATLMQ VHSEDHVEKS RKFVALSNTP LVPYTSRYPV
     VVYLPKDAEL RYSIWCGGEQ MQATTE