ID   ECOT1_LEIIN             Reviewed;         146 AA.
AC   A4HWD2;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Ecotin-like protein 1;
DE   AltName: Full=Inhibitor of serine peptidase 1;
DE            Short=LiISP1;
GN   Name=ISP1; ORFNames=LinJ15.0350, LinJ_15_0350;
OS   Leishmania infantum.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5;
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.-A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Sqaures R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
CC   -!- SIMILARITY: Belongs to the protease inhibitor I11 (ecotin) family.
CC       {ECO:0000305}.
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DR   EMBL; FR796447; CAM66755.1; -; Genomic_DNA.
DR   RefSeq; XP_001464373.1; XM_001464336.1.
DR   AlphaFoldDB; A4HWD2; -.
DR   SMR; A4HWD2; -.
DR   GeneID; 5067761; -.
DR   KEGG; lif:LINJ_15_0350; -.
DR   VEuPathDB; TriTrypDB:LINF_150008400; -.
DR   eggNOG; ENOG502SNN7; Eukaryota.
DR   InParanoid; A4HWD2; -.
DR   OMA; NDAANHQ; -.
DR   Proteomes; UP000008153; Chromosome 15.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   InterPro; IPR036198; Ecotin_sf.
DR   InterPro; IPR005658; Prot_inh_ecotin.
DR   PANTHER; PTHR35890; PTHR35890; 1.
DR   Pfam; PF03974; Ecotin; 1.
DR   SUPFAM; SSF49772; SSF49772; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..146
FT                   /note="Ecotin-like protein 1"
FT                   /id="PRO_0000291591"
SQ   SEQUENCE   146 AA;  16489 MW;  7683A8C06F1C0EBD CRC64;
     MSYCKIEAPY PTAEAGEKRI IFALDPKGDE AEQEQYMLQL IPGRVLEMSR NDAANHQTLG
     GSIEQHTVEG WGAKFFHVKL AKQAASTLMH VHDEDHSEKV RKFVAMPNPP LFPYRSRCPV
     VVYLPNDAEL RYGIWCGGQQ MQAVTE