ID   ECOT1_LEIMA             Reviewed;         146 AA.
AC   Q4QFF0;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Ecotin-like protein 1;
DE   AltName: Full=Inhibitor of serine peptidase 1;
DE            Short=LmISP1;
GN   Name=ISP1; ORFNames=LmjF15.0300, LmjF_15_0300;
OS   Leishmania major.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5664;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/IL/81/Friedlin;
RX   PubMed=16020728; DOI=10.1126/science.1112680;
RA   Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA   Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA   Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA   Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA   Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M.,
RA   De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA   Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA   Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA   Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA   Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S.,
RA   Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA   Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA   Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA   Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K.,
RA   Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA   Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA   Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA   Barrell B.G., Myler P.J.;
RT   "The genome of the kinetoplastid parasite, Leishmania major.";
RL   Science 309:436-442(2005).
CC   -!- SIMILARITY: Belongs to the protease inhibitor I11 (ecotin) family.
CC       {ECO:0000305}.
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DR   EMBL; FR796411; CAJ03258.1; -; Genomic_DNA.
DR   RefSeq; XP_001681948.1; XM_001681896.1.
DR   AlphaFoldDB; Q4QFF0; -.
DR   SMR; Q4QFF0; -.
DR   MEROPS; I11.002; -.
DR   EnsemblProtists; CAJ03258; CAJ03258; LMJF_15_0300.
DR   GeneID; 5650388; -.
DR   KEGG; lma:LMJF_15_0300; -.
DR   VEuPathDB; TriTrypDB:LmjF.15.0300; -.
DR   VEuPathDB; TriTrypDB:LMJLV39_150008900; -.
DR   VEuPathDB; TriTrypDB:LMJSD75_150008800; -.
DR   eggNOG; ENOG502SNN7; Eukaryota.
DR   InParanoid; Q4QFF0; -.
DR   OMA; NDAANHQ; -.
DR   Proteomes; UP000000542; Chromosome 15.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   InterPro; IPR036198; Ecotin_sf.
DR   InterPro; IPR005658; Prot_inh_ecotin.
DR   PANTHER; PTHR35890; PTHR35890; 1.
DR   Pfam; PF03974; Ecotin; 1.
DR   SUPFAM; SSF49772; SSF49772; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..146
FT                   /note="Ecotin-like protein 1"
FT                   /id="PRO_0000291592"
SQ   SEQUENCE   146 AA;  16454 MW;  AF88356D284C6E8A CRC64;
     MSYCKIEAPY PEAEAGEKRI IFALDPKGDE VEQEQCMLQL IPGRVLEMSR NDAANHQTLG
     GSIEQHTVEG FGAKFFHVKL AKQAVSTLMY VHAEDHGEKV RKFVAMSNAP MFPYRSRYPV
     VVYLPKDAEL RYGIWCGGQQ MQAATE