ID   ECOT2_LEIMA             Reviewed;         158 AA.
AC   Q4QFD4;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Ecotin-like protein 2;
GN   ORFNames=LmjF15.0510, LmjF_15_0510;
OS   Leishmania major.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5664;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/IL/81/Friedlin;
RX   PubMed=16020728; DOI=10.1126/science.1112680;
RA   Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA   Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA   Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA   Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA   Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M.,
RA   De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA   Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA   Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA   Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA   Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S.,
RA   Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA   Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA   Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA   Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K.,
RA   Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA   Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA   Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA   Barrell B.G., Myler P.J.;
RT   "The genome of the kinetoplastid parasite, Leishmania major.";
RL   Science 309:436-442(2005).
CC   -!- SIMILARITY: Belongs to the protease inhibitor I11 (ecotin) family.
CC       {ECO:0000305}.
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DR   EMBL; FR796411; CAJ03275.1; -; Genomic_DNA.
DR   RefSeq; XP_001681964.1; XM_001681912.1.
DR   AlphaFoldDB; Q4QFD4; -.
DR   SMR; Q4QFD4; -.
DR   STRING; 5664.LmjF.15.0510; -.
DR   MEROPS; I11.003; -.
DR   EnsemblProtists; CAJ03275; CAJ03275; LMJF_15_0510.
DR   GeneID; 5650427; -.
DR   KEGG; lma:LMJF_15_0510; -.
DR   VEuPathDB; TriTrypDB:LmjF.15.0510; -.
DR   VEuPathDB; TriTrypDB:LMJLV39_150010900; -.
DR   VEuPathDB; TriTrypDB:LMJSD75_150010900; -.
DR   eggNOG; ENOG502S3WU; Eukaryota.
DR   InParanoid; Q4QFD4; -.
DR   OMA; PKAEKGM; -.
DR   Proteomes; UP000000542; Chromosome 15.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   GO; GO:0042784; P:evasion of host immune response via regulation of host complement system; IMP:GeneDB.
DR   CDD; cd00242; Ecotin; 1.
DR   InterPro; IPR036198; Ecotin_sf.
DR   InterPro; IPR005658; Prot_inh_ecotin.
DR   InterPro; IPR023084; Prot_inh_ecotin_gammaproteobac.
DR   PANTHER; PTHR35890; PTHR35890; 1.
DR   Pfam; PF03974; Ecotin; 1.
DR   SUPFAM; SSF49772; SSF49772; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..158
FT                   /note="Ecotin-like protein 2"
FT                   /id="PRO_0000291595"
SQ   SEQUENCE   158 AA;  17847 MW;  83BD667F806EC7E8 CRC64;
     MPAGMSDAAG KTLADFKAPY PEPTSQQRRY VIFLDPKGDS KELNDYKVEL IPGRVEKVDG
     TNVYRMGGNI EERTIDGWGY PYYIVTLTTM SGTLMMPLGD AALKRPRFVA MNTKNLYRYN
     SRLPIVVYMP KDGELRYRIW TVKSTGSGTA KSTKAREM