ID   ECOT2_TRYB2             Reviewed;         154 AA.
AC   Q57ZQ7;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Ecotin-like protein 2;
GN   ORFNames=Tb927.5.1880;
OS   Trypanosoma brucei brucei (strain 927/4 GUTat10.1).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=185431;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=927/4 GUTat10.1 {ECO:0000312|Proteomes:UP000008524};
RX   PubMed=16020726; DOI=10.1126/science.1112642;
RA   Berriman M., Ghedin E., Hertz-Fowler C., Blandin G., Renauld H.,
RA   Bartholomeu D.C., Lennard N.J., Caler E., Hamlin N.E., Haas B., Bohme U.,
RA   Hannick L., Aslett M.A., Shallom J., Marcello L., Hou L., Wickstead B.,
RA   Alsmark U.C.M., Arrowsmith C., Atkin R.J., Barron A.J., Bringaud F.,
RA   Brooks K., Carrington M., Cherevach I., Chillingworth T.J., Churcher C.,
RA   Clark L.N., Corton C.H., Cronin A., Davies R.M., Doggett J., Djikeng A.,
RA   Feldblyum T., Field M.C., Fraser A., Goodhead I., Hance Z., Harper D.,
RA   Harris B.R., Hauser H., Hostetler J., Ivens A., Jagels K., Johnson D.,
RA   Johnson J., Jones K., Kerhornou A.X., Koo H., Larke N., Landfear S.,
RA   Larkin C., Leech V., Line A., Lord A., Macleod A., Mooney P.J., Moule S.,
RA   Martin D.M., Morgan G.W., Mungall K., Norbertczak H., Ormond D., Pai G.,
RA   Peacock C.S., Peterson J., Quail M.A., Rabbinowitsch E., Rajandream M.A.,
RA   Reitter C., Salzberg S.L., Sanders M., Schobel S., Sharp S., Simmonds M.,
RA   Simpson A.J., Tallon L., Turner C.M., Tait A., Tivey A.R., Van Aken S.,
RA   Walker D., Wanless D., Wang S., White B., White O., Whitehead S.,
RA   Woodward J., Wortman J., Adams M.D., Embley T.M., Gull K., Ullu E.,
RA   Barry J.D., Fairlamb A.H., Opperdoes F., Barrell B.G., Donelson J.E.,
RA   Hall N., Fraser C.M., Melville S.E., El-Sayed N.M.A.;
RT   "The genome of the African trypanosome Trypanosoma brucei.";
RL   Science 309:416-422(2005).
CC   -!- SIMILARITY: Belongs to the protease inhibitor I11 (ecotin) family.
CC       {ECO:0000305}.
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DR   EMBL; AC104617; AAX79109.1; -; Genomic_DNA.
DR   RefSeq; XP_844862.1; XM_839769.1.
DR   AlphaFoldDB; Q57ZQ7; -.
DR   SMR; Q57ZQ7; -.
DR   PaxDb; Q57ZQ7; -.
DR   GeneID; 3657301; -.
DR   KEGG; tbr:Tb927.5.1880; -.
DR   VEuPathDB; TriTrypDB:Tb927.5.1880; -.
DR   InParanoid; Q57ZQ7; -.
DR   OMA; PKAEKGM; -.
DR   Proteomes; UP000008524; Chromosome 5.
DR   GO; GO:0097740; C:paraflagellar rod; IDA:GeneDB.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   GO; GO:0042784; P:evasion of host immune response via regulation of host complement system; ISO:GeneDB.
DR   Gene3D; 4.10.1230.10; -; 1.
DR   InterPro; IPR027438; Ecotin_C.
DR   InterPro; IPR036198; Ecotin_sf.
DR   InterPro; IPR005658; Prot_inh_ecotin.
DR   PANTHER; PTHR35890; PTHR35890; 1.
DR   Pfam; PF03974; Ecotin; 1.
DR   PIRSF; PIRSF006865; Prot_inh_ecotin; 1.
DR   SUPFAM; SSF49772; SSF49772; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..154
FT                   /note="Ecotin-like protein 2"
FT                   /id="PRO_0000291609"
SQ   SEQUENCE   154 AA;  17810 MW;  754589E0DA7110BC CRC64;
     MTDRPPTLAD FKAPYPEPGP DQTCCIILLE EKPDEEENYR VELIPGRVME DGLATGTVSG
     VVREEVIHGW GYSYYVVEME PLVTTRRSIR SFHRPTRFVP VPTKHFIRYN SQLPVVVYLP
     HNTELRYRVW TPIDMQKVEP TEPEGLLKIE ERAG