ID   ECOT3_LEIBR             Reviewed;         309 AA.
AC   A4H824;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Ecotin-like protein 3;
GN   ORFNames=LbrM15_V2.0550, LbrM_15_0550;
OS   Leishmania braziliensis.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania;
OC   Leishmania braziliensis species complex.
OX   NCBI_TaxID=5660;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/BR/75/M2904;
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.-A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Sqaures R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
CC   -!- SIMILARITY: Belongs to the protease inhibitor I11 (ecotin) family.
CC       {ECO:0000305}.
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DR   EMBL; FR798989; CAM42072.1; -; Genomic_DNA.
DR   RefSeq; XP_001563503.1; XM_001563453.1.
DR   AlphaFoldDB; A4H824; -.
DR   SMR; A4H824; -.
DR   MEROPS; I11.004; -.
DR   GeneID; 5414021; -.
DR   KEGG; lbz:LBRM_15_0550; -.
DR   VEuPathDB; TriTrypDB:LbrM.15.0550; -.
DR   VEuPathDB; TriTrypDB:LBRM2903_150011300; -.
DR   InParanoid; A4H824; -.
DR   OMA; PGRHENC; -.
DR   Proteomes; UP000007258; Chromosome 15.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 4.10.1230.10; -; 1.
DR   InterPro; IPR027438; Ecotin_C.
DR   InterPro; IPR036198; Ecotin_sf.
DR   InterPro; IPR005658; Prot_inh_ecotin.
DR   PANTHER; PTHR35890; PTHR35890; 2.
DR   Pfam; PF03974; Ecotin; 1.
DR   SUPFAM; SSF49772; SSF49772; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..309
FT                   /note="Ecotin-like protein 3"
FT                   /id="PRO_0000291597"
FT   REGION          140..309
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        178..192
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        193..222
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        230..250
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        253..283
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   309 AA;  34527 MW;  53E6C6E70BEEEBF2 CRC64;
     MPSLEDYRIP YPAAGPCQKR TVIYLPQQDS AVEQHHLRVQ LIPGRHVRCE DGCFYQLTGT
     VSEETLQSWG YPYYVVTLDD IYPAQCSPSD PANPRTFVPL RESPMIPYNS KRPIVVYVPE
     DAEVRYRVWC SDVLQVQESQ QELEAPAVSQ SCPVPVRERQ NNPEGHAHPV VVHSVESPEV
     SGHKDGDQPM KKSSKLKQSC SNSSRSLKHS ASGSSPKNTP LFSRESVPPE HSLSAAQQRR
     RSNENSAIDE TGGGASRKKR SDSTSSRKDD QDSGYEKKVK NLWNRARGNS SPKRSASPKK
     SGRDSRRNS