ID   ECOT3_LEIIN             Reviewed;         378 AA.
AC   A4HWF0;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2007, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Ecotin-like protein 3;
GN   ORFNames=LinJ15.0540, LinJ_15_0540;
OS   Leishmania infantum.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5671;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JPCM5;
RX   PubMed=17572675; DOI=10.1038/ng2053;
RA   Peacock C.S., Seeger K., Harris D., Murphy L., Ruiz J.C., Quail M.A.,
RA   Peters N., Adlem E., Tivey A., Aslett M., Kerhornou A., Ivens A.,
RA   Fraser A., Rajandream M.-A., Carver T., Norbertczak H., Chillingworth T.,
RA   Hance Z., Jagels K., Moule S., Ormond D., Rutter S., Sqaures R.,
RA   Whitehead S., Rabbinowitsch E., Arrowsmith C., White B., Thurston S.,
RA   Bringaud F., Baldauf S.L., Faulconbridge A., Jeffares D., Depledge D.P.,
RA   Oyola S.O., Hilley J.D., Brito L.O., Tosi L.R.O., Barrell B., Cruz A.K.,
RA   Mottram J.C., Smith D.F., Berriman M.;
RT   "Comparative genomic analysis of three Leishmania species that cause
RT   diverse human disease.";
RL   Nat. Genet. 39:839-847(2007).
CC   -!- SIMILARITY: Belongs to the protease inhibitor I11 (ecotin) family.
CC       {ECO:0000305}.
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DR   EMBL; FR796447; CAM66775.1; -; Genomic_DNA.
DR   RefSeq; XP_001464391.1; XM_001464354.1.
DR   AlphaFoldDB; A4HWF0; -.
DR   SMR; A4HWF0; -.
DR   MEROPS; I11.004; -.
DR   PRIDE; A4HWF0; -.
DR   GeneID; 5067781; -.
DR   KEGG; lif:LINJ_15_0540; -.
DR   VEuPathDB; TriTrypDB:LINF_150012500; -.
DR   eggNOG; ENOG502SM48; Eukaryota.
DR   InParanoid; A4HWF0; -.
DR   OMA; PGRHENC; -.
DR   Proteomes; UP000008153; Chromosome 15.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   Gene3D; 4.10.1230.10; -; 1.
DR   InterPro; IPR027438; Ecotin_C.
DR   InterPro; IPR036198; Ecotin_sf.
DR   InterPro; IPR005658; Prot_inh_ecotin.
DR   PANTHER; PTHR35890; PTHR35890; 1.
DR   Pfam; PF03974; Ecotin; 1.
DR   SUPFAM; SSF49772; SSF49772; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..378
FT                   /note="Ecotin-like protein 3"
FT                   /id="PRO_0000291598"
FT   REGION          191..216
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          238..378
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        255..290
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        338..356
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        357..378
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   378 AA;  41729 MW;  08E354A8F20723F7 CRC64;
     MPSLQDYHVP YPAAAPGQVR KVIYLPQQNP TVEQQHLRVQ IIPGRHENCE DGRLYKLTGS
     VTEETLQGWG YSYYVVKLGD IYAAHRSSSD PARVTTFVAL DENPVIAYNS KLPIVVYVPE
     GAELRYRVWT DDTSLVQSIQ QQPEAPALPQ PHLVPVTERQ ECPHELPRCG APGEYVTQDC
     KTSMLSVEEV HRLSSSTPPL IPSAVRGSAH EAHAAPPLHS AELEERVCPV MEHLEVCPQN
     NGHEGREQPA EEASTLKRRS SSSSSSNPRH HSANEPSPSR PRLSSTEYWP HENSKTKRSP
     SATHKPRRST DSAAIEEAGV GAPKKNRSSS SSASSKRKAE DNVYEKTMKN FWNRARSDSP
     RKASASSKKS GNGSKADP