ID   ECOT3_LEIMA             Reviewed;         381 AA.
AC   Q4QFD3;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Ecotin-like protein 3;
GN   ORFNames=LmjF15.0520, LmjF_15_0520;
OS   Leishmania major.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Leishmaniinae; Leishmania.
OX   NCBI_TaxID=5664;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MHOM/IL/81/Friedlin;
RX   PubMed=16020728; DOI=10.1126/science.1112680;
RA   Ivens A.C., Peacock C.S., Worthey E.A., Murphy L., Aggarwal G.,
RA   Berriman M., Sisk E., Rajandream M.A., Adlem E., Aert R., Anupama A.,
RA   Apostolou Z., Attipoe P., Bason N., Bauser C., Beck A., Beverley S.M.,
RA   Bianchettin G., Borzym K., Bothe G., Bruschi C.V., Collins M., Cadag E.,
RA   Ciarloni L., Clayton C., Coulson R.M.R., Cronin A., Cruz A.K., Davies R.M.,
RA   De Gaudenzi J., Dobson D.E., Duesterhoeft A., Fazelina G., Fosker N.,
RA   Frasch A.C., Fraser A., Fuchs M., Gabel C., Goble A., Goffeau A.,
RA   Harris D., Hertz-Fowler C., Hilbert H., Horn D., Huang Y., Klages S.,
RA   Knights A., Kube M., Larke N., Litvin L., Lord A., Louie T., Marra M.,
RA   Masuy D., Matthews K., Michaeli S., Mottram J.C., Mueller-Auer S.,
RA   Munden H., Nelson S., Norbertczak H., Oliver K., O'neil S., Pentony M.,
RA   Pohl T.M., Price C., Purnelle B., Quail M.A., Rabbinowitsch E.,
RA   Reinhardt R., Rieger M., Rinta J., Robben J., Robertson L., Ruiz J.C.,
RA   Rutter S., Saunders D., Schaefer M., Schein J., Schwartz D.C., Seeger K.,
RA   Seyler A., Sharp S., Shin H., Sivam D., Squares R., Squares S., Tosato V.,
RA   Vogt C., Volckaert G., Wambutt R., Warren T., Wedler H., Woodward J.,
RA   Zhou S., Zimmermann W., Smith D.F., Blackwell J.M., Stuart K.D.,
RA   Barrell B.G., Myler P.J.;
RT   "The genome of the kinetoplastid parasite, Leishmania major.";
RL   Science 309:436-442(2005).
CC   -!- SIMILARITY: Belongs to the protease inhibitor I11 (ecotin) family.
CC       {ECO:0000305}.
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DR   EMBL; FR796411; CAJ03276.1; -; Genomic_DNA.
DR   RefSeq; XP_001681965.1; XM_001681913.1.
DR   AlphaFoldDB; Q4QFD3; -.
DR   SMR; Q4QFD3; -.
DR   MEROPS; I11.004; -.
DR   EnsemblProtists; CAJ03276; CAJ03276; LMJF_15_0520.
DR   GeneID; 5650428; -.
DR   KEGG; lma:LMJF_15_0520; -.
DR   VEuPathDB; TriTrypDB:LmjF.15.0520; -.
DR   VEuPathDB; TriTrypDB:LMJLV39_150011000; -.
DR   VEuPathDB; TriTrypDB:LMJSD75_150011000; -.
DR   eggNOG; ENOG502SM48; Eukaryota.
DR   InParanoid; Q4QFD3; -.
DR   OMA; PGRHENC; -.
DR   Proteomes; UP000000542; Chromosome 15.
DR   GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR   GO; GO:0042784; P:evasion of host immune response via regulation of host complement system; IMP:GeneDB.
DR   Gene3D; 4.10.1230.10; -; 1.
DR   InterPro; IPR027438; Ecotin_C.
DR   InterPro; IPR036198; Ecotin_sf.
DR   InterPro; IPR005658; Prot_inh_ecotin.
DR   PANTHER; PTHR35890; PTHR35890; 1.
DR   Pfam; PF03974; Ecotin; 1.
DR   SUPFAM; SSF49772; SSF49772; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..381
FT                   /note="Ecotin-like protein 3"
FT                   /id="PRO_0000291599"
FT   REGION          232..381
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        254..296
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        333..355
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        356..373
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   381 AA;  41839 MW;  31FF74B1F8DF7A8D CRC64;
     MPSLQDYHVP YPAAAPGQVR KVIYLPRQNP TVEQQHLRVQ IIPGRHENCD DGRLYKLTGS
     VTEETLQGWG YSYYVVTLGD IYAAHRSSSD PARATTFVAL DESPVIAYNS KLPIVVYVPE
     GAELRYRIWT DDASLAQSIQ QKPEAPALPQ PHLVPVTEGQ ECPQELPRCG APSEYVRQDY
     KASMLSVEEV HRLSNNTPPL IPSAVHESAH EAHAAPPLHS AVLEEHGRPG MEHLEVCPKN
     NGSEGREQPA EEASTLKQRS SSSSSNPRHH SANESSPSRP RLSSTAYWPQ ENSKTKRSPS
     ATHKPRRSTD SAAIEETGVG TPKKNRSSSG SASNKRKAED DVYEKTMKNF WNRARSDSPR
     KASASSTKSG NGSKADPVDG K