ECOT_PSEAE
ID ECOT_PSEAE Reviewed; 156 AA.
AC Q9I088;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Ecotin {ECO:0000255|HAMAP-Rule:MF_00706};
DE Flags: Precursor;
GN Name=eco {ECO:0000255|HAMAP-Rule:MF_00706}; OrderedLocusNames=PA2755;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- FUNCTION: General inhibitor of family S1 serine proteases.
CC {ECO:0000255|HAMAP-Rule:MF_00706}.
CC -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00706}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000255|HAMAP-Rule:MF_00706}.
CC -!- SIMILARITY: Belongs to the protease inhibitor I11 (ecotin) family.
CC {ECO:0000255|HAMAP-Rule:MF_00706}.
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DR EMBL; AE004091; AAG06143.1; -; Genomic_DNA.
DR PIR; B83302; B83302.
DR RefSeq; NP_251445.1; NC_002516.2.
DR RefSeq; WP_003114416.1; NZ_QZGE01000011.1.
DR AlphaFoldDB; Q9I088; -.
DR SMR; Q9I088; -.
DR STRING; 287.DR97_5198; -.
DR MEROPS; I11.003; -.
DR PaxDb; Q9I088; -.
DR PRIDE; Q9I088; -.
DR DNASU; 882725; -.
DR EnsemblBacteria; AAG06143; AAG06143; PA2755.
DR GeneID; 882725; -.
DR KEGG; pae:PA2755; -.
DR PATRIC; fig|208964.12.peg.2889; -.
DR PseudoCAP; PA2755; -.
DR HOGENOM; CLU_111565_0_0_6; -.
DR InParanoid; Q9I088; -.
DR OMA; PKAEKGM; -.
DR PhylomeDB; Q9I088; -.
DR BioCyc; PAER208964:G1FZ6-2800-MON; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-UniRule.
DR CDD; cd00242; Ecotin; 1.
DR Gene3D; 4.10.1230.10; -; 1.
DR HAMAP; MF_00706; Ecotin; 1.
DR InterPro; IPR027438; Ecotin_C.
DR InterPro; IPR036198; Ecotin_sf.
DR InterPro; IPR005658; Prot_inh_ecotin.
DR InterPro; IPR023084; Prot_inh_ecotin_gammaproteobac.
DR PANTHER; PTHR35890; PTHR35890; 1.
DR Pfam; PF03974; Ecotin; 1.
DR PIRSF; PIRSF006865; Prot_inh_ecotin; 1.
DR SUPFAM; SSF49772; SSF49772; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Periplasm; Protease inhibitor; Reference proteome;
KW Serine protease inhibitor; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00706"
FT CHAIN 20..156
FT /note="Ecotin"
FT /id="PRO_0000007427"
FT SITE 99..100
FT /note="Reactive bond"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00706"
FT DISULFID 65..102
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00706"
SQ SEQUENCE 156 AA; 17228 MW; E0E1DE2D7B6E2A53 CRC64;
MKALLIAAGV AALSSTAMAA KLDEKVPYPK ADAGFTRQVI HLPKQDAEDA FKVEIIAGKT
LEADCNQQRL GGELEEHTLE GWGYSYYRLD KVSGPMSTMM ACPGQKKEQR FIPVVGEGFL
LCYNSKLPIV VYAPKDVEVR YRIWSASEKV EKAVSE
