ECPA_ECO81
ID ECPA_ECO81 Reviewed; 195 AA.
AC P0C900; B7MP74; Q9AME1;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-APR-2009, sequence version 1.
DT 25-MAY-2022, entry version 46.
DE RecName: Full=Common pilus major fimbrillin subunit EcpA;
DE AltName: Full=MatB fimbrillin;
DE Flags: Precursor;
GN Name=ecpA; Synonyms=matB; OrderedLocusNames=ECED1_0335;
OS Escherichia coli O81 (strain ED1a).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=585397;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ED1a;
RX PubMed=19165319; DOI=10.1371/journal.pgen.1000344;
RA Touchon M., Hoede C., Tenaillon O., Barbe V., Baeriswyl S., Bidet P.,
RA Bingen E., Bonacorsi S., Bouchier C., Bouvet O., Calteau A., Chiapello H.,
RA Clermont O., Cruveiller S., Danchin A., Diard M., Dossat C., Karoui M.E.,
RA Frapy E., Garry L., Ghigo J.M., Gilles A.M., Johnson J., Le Bouguenec C.,
RA Lescat M., Mangenot S., Martinez-Jehanne V., Matic I., Nassif X., Oztas S.,
RA Petit M.A., Pichon C., Rouy Z., Ruf C.S., Schneider D., Tourret J.,
RA Vacherie B., Vallenet D., Medigue C., Rocha E.P.C., Denamur E.;
RT "Organised genome dynamics in the Escherichia coli species results in
RT highly diverse adaptive paths.";
RL PLoS Genet. 5:E1000344-E1000344(2009).
CC -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli common
CC pilus (ECP). ECP is found in both commensal and pathogenic strains and
CC plays a dual role in early-stage biofilm development and host cell
CC recognition. Major subunit of the fimbria (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Self-associates. Forms filaments. Interacts with EcpD (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000250}.
CC -!- INDUCTION: Negatively regulated by H-NS. Positively regulated by IHF
CC and EcpR (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the EcpA/MatB fimbrillin family. {ECO:0000305}.
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DR EMBL; CU928162; CAR06546.1; -; Genomic_DNA.
DR RefSeq; WP_000730982.1; NC_011745.1.
DR AlphaFoldDB; P0C900; -.
DR SMR; P0C900; -.
DR EnsemblBacteria; CAR06546; CAR06546; ECED1_0335.
DR KEGG; ecq:ECED1_0335; -.
DR HOGENOM; CLU_120328_0_0_6; -.
DR OMA; AQDQFTF; -.
DR Proteomes; UP000000748; Chromosome.
DR GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.3290; -; 1.
DR InterPro; IPR016514; EcpA.
DR InterPro; IPR038478; Fimbrillin_EcpA_sf.
DR Pfam; PF16449; MatB; 1.
DR PIRSF; PIRSF007320; Fimbrillin_MatB; 1.
PE 3: Inferred from homology;
KW Fimbrium; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..195
FT /note="Common pilus major fimbrillin subunit EcpA"
FT /id="PRO_0000367931"
SQ SEQUENCE 195 AA; 20081 MW; E0601C888446758C CRC64;
MKKKVLAIAL VTVFTGTGVA QAADVTAQAV ATWSATAKKD TTSKLVVTPL GSLAFQYAEG
IKGFNSQKGL FDVAIEGDST ATAFKLTSRL ITNTLTQLDT SGSTLNVGVD YNGAAVEKTG
DTVMIDTANG VLGGNLSPLA NGYNASNRTT AQDGFTFSII SGTTNGTTAV TDYSTLPEGI
WSGDVSVQFD ATWTS