ECPA_ECODH
ID ECPA_ECODH Reviewed; 195 AA.
AC B1XE35;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 20-MAY-2008, sequence version 1.
DT 03-AUG-2022, entry version 58.
DE RecName: Full=Common pilus major fimbrillin subunit EcpA;
DE AltName: Full=MatB fimbrillin;
DE Flags: Precursor;
GN Name=ecpA; Synonyms=matB; OrderedLocusNames=ECDH10B_0281;
OS Escherichia coli (strain K12 / DH10B).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=316385;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / DH10B;
RX PubMed=18245285; DOI=10.1128/jb.01695-07;
RA Durfee T., Nelson R., Baldwin S., Plunkett G. III, Burland V., Mau B.,
RA Petrosino J.F., Qin X., Muzny D.M., Ayele M., Gibbs R.A., Csorgo B.,
RA Posfai G., Weinstock G.M., Blattner F.R.;
RT "The complete genome sequence of Escherichia coli DH10B: insights into the
RT biology of a laboratory workhorse.";
RL J. Bacteriol. 190:2597-2606(2008).
CC -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli common
CC pilus (ECP). ECP is found in both commensal and pathogenic strains and
CC plays a dual role in early-stage biofilm development and host cell
CC recognition. Major subunit of the fimbria (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Self-associates. Forms filaments. Interacts with EcpD (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000250}.
CC -!- INDUCTION: Negatively regulated by H-NS. Positively regulated by IHF
CC and EcpR (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the EcpA/MatB fimbrillin family. {ECO:0000305}.
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DR EMBL; CP000948; ACB01459.1; -; Genomic_DNA.
DR RefSeq; WP_000730972.1; NC_010473.1.
DR AlphaFoldDB; B1XE35; -.
DR SMR; B1XE35; -.
DR KEGG; ecd:ECDH10B_0281; -.
DR HOGENOM; CLU_120328_0_0_6; -.
DR OMA; AQDQFTF; -.
DR BioCyc; ECOL316385:ECDH10B_RS01425-MON; -.
DR GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.3290; -; 1.
DR InterPro; IPR016514; EcpA.
DR InterPro; IPR038478; Fimbrillin_EcpA_sf.
DR Pfam; PF16449; MatB; 1.
DR PIRSF; PIRSF007320; Fimbrillin_MatB; 1.
PE 3: Inferred from homology;
KW Fimbrium; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..195
FT /note="Common pilus major fimbrillin subunit EcpA"
FT /id="PRO_0000367922"
SQ SEQUENCE 195 AA; 20111 MW; 60791615380A2A44 CRC64;
MKKKVLAIAL VTVFTGMGVA QAADVTAQAV ATWSATAKKD TTSKLVVTPL GSLAFQYAEG
IKGFNSQKGL FDVAIEGDST ATAFKLTSRL ITNTLTQLDT SGSTLNVGVD YNGAAVEKTG
DTVMIDTANG VLGGNLSPLA NGYNASNRTT AQDGFTFSII SGTTNGTTAV TDYSTLPEGI
WSGDVSVQFD ATWTS