ECPA_ECOLC
ID ECPA_ECOLC Reviewed; 195 AA.
AC B1J0X9;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 25-MAY-2022, entry version 58.
DE RecName: Full=Common pilus major fimbrillin subunit EcpA;
DE AltName: Full=MatB fimbrillin;
DE Flags: Precursor;
GN Name=ecpA; Synonyms=matB; OrderedLocusNames=EcolC_3326;
OS Escherichia coli (strain ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 /
OS WDCM 00012 / Crooks).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=481805;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8739 / DSM 1576 / NBRC 3972 / NCIMB 8545 / WDCM 00012 / Crooks;
RA Copeland A., Lucas S., Lapidus A., Glavina del Rio T., Dalin E., Tice H.,
RA Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C.,
RA Kuske C.R., Schmutz J., Larimer F., Land M., Hauser L., Kyrpides N.,
RA Mikhailova N., Ingram L., Richardson P.;
RT "Complete sequence of Escherichia coli C str. ATCC 8739.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli common
CC pilus (ECP). ECP is found in both commensal and pathogenic strains and
CC plays a dual role in early-stage biofilm development and host cell
CC recognition. Major subunit of the fimbria (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Self-associates. Forms filaments. Interacts with EcpD (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000250}.
CC -!- INDUCTION: Negatively regulated by H-NS. Positively regulated by IHF
CC and EcpR (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the EcpA/MatB fimbrillin family. {ECO:0000305}.
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DR EMBL; CP000946; ACA78947.1; -; Genomic_DNA.
DR RefSeq; WP_000730974.1; NZ_CP022959.1.
DR AlphaFoldDB; B1J0X9; -.
DR SMR; B1J0X9; -.
DR GeneID; 66671412; -.
DR KEGG; ecl:EcolC_3326; -.
DR HOGENOM; CLU_120328_0_0_6; -.
DR OMA; AQDQFTF; -.
DR GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.3290; -; 1.
DR InterPro; IPR016514; EcpA.
DR InterPro; IPR038478; Fimbrillin_EcpA_sf.
DR Pfam; PF16449; MatB; 1.
DR PIRSF; PIRSF007320; Fimbrillin_MatB; 1.
PE 3: Inferred from homology;
KW Fimbrium; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..195
FT /note="Common pilus major fimbrillin subunit EcpA"
FT /id="PRO_5000314440"
SQ SEQUENCE 195 AA; 20125 MW; 7B791615380E7B01 CRC64;
MKKKVLAIAL VTVFTGMGVA QAADVTAQAV ATWSATAKKD TTSKLVVTPL GSLAFQYAEG
IKGFNSQKGL FDVAIEGDST ATAFKLTSRL ITNTLTQLDT SGSTLNVGVD YNGAAVEKTG
DTVMIDTANG VLGGNLSPLA NGYNASNRTT AQDGFTFTII SGTTNGTTAV TDYSTLPEGI
WSGDVSVQFD ATWTS