ID   ECPA_ECOLX              Reviewed;         195 AA.
AC   P0C8Z9; Q9AME1;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-APR-2009, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Common pilus major fimbrillin subunit EcpA;
DE   AltName: Full=MatB fimbrillin;
DE   Flags: Precursor;
GN   Name=ecpA; Synonyms=matB;
OS   Escherichia coli.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LF82 / AIEC;
RA   Peyretaillade E., Claret L., Bonnet R., Dossat C., Barbe V., Vacherie B.,
RA   Segurens B., Peyret P., Darfeuille-Michaud A.;
RT   "Complete genome sequence of adherent invasive Escherichia coli strain LF82
RT   isolated from a patient with Crohn's disease.";
RL   Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli common
CC       pilus (ECP). ECP is found in both commensal and pathogenic strains and
CC       plays a dual role in early-stage biofilm development and host cell
CC       recognition. Major subunit of the fimbria (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Self-associates. Forms filaments. Interacts with EcpD (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000250}.
CC   -!- INDUCTION: Negatively regulated by H-NS. Positively regulated by IHF
CC       and EcpR (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EcpA/MatB fimbrillin family. {ECO:0000305}.
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DR   EMBL; CU651637; CAP74843.1; -; Genomic_DNA.
DR   RefSeq; WP_000730982.1; NZ_WWEV01000006.1.
DR   AlphaFoldDB; P0C8Z9; -.
DR   SMR; P0C8Z9; -.
DR   STRING; 585034.ECIAI1_0294; -.
DR   KEGG; elf:LF82_1280; -.
DR   PATRIC; fig|591946.4.peg.282; -.
DR   eggNOG; ENOG502Z9JQ; Bacteria.
DR   HOGENOM; CLU_120328_0_0_6; -.
DR   OMA; AQDQFTF; -.
DR   OrthoDB; 1278899at2; -.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.3290; -; 1.
DR   InterPro; IPR016514; EcpA.
DR   InterPro; IPR038478; Fimbrillin_EcpA_sf.
DR   Pfam; PF16449; MatB; 1.
DR   PIRSF; PIRSF007320; Fimbrillin_MatB; 1.
PE   3: Inferred from homology;
KW   Fimbrium; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..195
FT                   /note="Common pilus major fimbrillin subunit EcpA"
FT                   /id="PRO_0000367921"
SQ   SEQUENCE   195 AA;  20081 MW;  E0601C888446758C CRC64;
     MKKKVLAIAL VTVFTGTGVA QAADVTAQAV ATWSATAKKD TTSKLVVTPL GSLAFQYAEG
     IKGFNSQKGL FDVAIEGDST ATAFKLTSRL ITNTLTQLDT SGSTLNVGVD YNGAAVEKTG
     DTVMIDTANG VLGGNLSPLA NGYNASNRTT AQDGFTFSII SGTTNGTTAV TDYSTLPEGI
     WSGDVSVQFD ATWTS