ECPA_ECOSE
ID ECPA_ECOSE Reviewed; 195 AA.
AC B6I081;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 1.
DT 25-MAY-2022, entry version 51.
DE RecName: Full=Common pilus major fimbrillin subunit EcpA;
DE AltName: Full=MatB fimbrillin;
DE Flags: Precursor;
GN Name=ecpA; Synonyms=matB; OrderedLocusNames=ECSE_0311;
OS Escherichia coli (strain SE11).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=409438;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SE11;
RX PubMed=18931093; DOI=10.1093/dnares/dsn026;
RA Oshima K., Toh H., Ogura Y., Sasamoto H., Morita H., Park S.-H., Ooka T.,
RA Iyoda S., Taylor T.D., Hayashi T., Itoh K., Hattori M.;
RT "Complete genome sequence and comparative analysis of the wild-type
RT commensal Escherichia coli strain SE11 isolated from a healthy adult.";
RL DNA Res. 15:375-386(2008).
CC -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli common
CC pilus (ECP). ECP is found in both commensal and pathogenic strains and
CC plays a dual role in early-stage biofilm development and host cell
CC recognition. Major subunit of the fimbria (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Self-associates. Forms filaments. Interacts with EcpD (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000250}.
CC -!- INDUCTION: Negatively regulated by H-NS. Positively regulated by IHF
CC and EcpR (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the EcpA/MatB fimbrillin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AP009240; BAG75835.1; -; Genomic_DNA.
DR RefSeq; WP_000730974.1; NC_011415.1.
DR AlphaFoldDB; B6I081; -.
DR SMR; B6I081; -.
DR EnsemblBacteria; BAG75835; BAG75835; ECSE_0311.
DR GeneID; 66671412; -.
DR KEGG; ecy:ECSE_0311; -.
DR HOGENOM; CLU_120328_0_0_6; -.
DR OMA; AQDQFTF; -.
DR Proteomes; UP000008199; Chromosome.
DR GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR Gene3D; 2.60.40.3290; -; 1.
DR InterPro; IPR016514; EcpA.
DR InterPro; IPR038478; Fimbrillin_EcpA_sf.
DR Pfam; PF16449; MatB; 1.
DR PIRSF; PIRSF007320; Fimbrillin_MatB; 1.
PE 3: Inferred from homology;
KW Fimbrium; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..195
FT /note="Common pilus major fimbrillin subunit EcpA"
FT /id="PRO_0000367923"
SQ SEQUENCE 195 AA; 20125 MW; 7B791615380E7B01 CRC64;
MKKKVLAIAL VTVFTGMGVA QAADVTAQAV ATWSATAKKD TTSKLVVTPL GSLAFQYAEG
IKGFNSQKGL FDVAIEGDST ATAFKLTSRL ITNTLTQLDT SGSTLNVGVD YNGAAVEKTG
DTVMIDTANG VLGGNLSPLA NGYNASNRTT AQDGFTFTII SGTTNGTTAV TDYSTLPEGI
WSGDVSVQFD ATWTS