ID   ECPA_KLEP3              Reviewed;         195 AA.
AC   B5Y158;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Common pilus major fimbrillin subunit EcpA;
DE   AltName: Full=MatB fimbrillin;
DE   Flags: Precursor;
GN   Name=ecpA; Synonyms=matB; OrderedLocusNames=KPK_4399;
OS   Klebsiella pneumoniae (strain 342).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=507522;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=342;
RX   PubMed=18654632; DOI=10.1371/journal.pgen.1000141;
RA   Fouts D.E., Tyler H.L., DeBoy R.T., Daugherty S., Ren Q., Badger J.H.,
RA   Durkin A.S., Huot H., Shrivastava S., Kothari S., Dodson R.J., Mohamoud Y.,
RA   Khouri H., Roesch L.F.W., Krogfelt K.A., Struve C., Triplett E.W.,
RA   Methe B.A.;
RT   "Complete genome sequence of the N2-fixing broad host range endophyte
RT   Klebsiella pneumoniae 342 and virulence predictions verified in mice.";
RL   PLoS Genet. 4:E1000141-E1000141(2008).
CC   -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli common
CC       pilus (ECP). ECP plays a dual role in early-stage biofilm development
CC       and host cell recognition. Major subunit of the fimbria (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Self-associates. Forms filaments. Interacts with EcpD (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000250}.
CC   -!- INDUCTION: Positively regulated by EcpR. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EcpA/MatB fimbrillin family. {ECO:0000305}.
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DR   EMBL; CP000964; ACI11765.1; -; Genomic_DNA.
DR   AlphaFoldDB; B5Y158; -.
DR   SMR; B5Y158; -.
DR   EnsemblBacteria; ACI11765; ACI11765; KPK_4399.
DR   KEGG; kpe:KPK_4399; -.
DR   HOGENOM; CLU_120328_0_0_6; -.
DR   OMA; AQDQFTF; -.
DR   OrthoDB; 1278899at2; -.
DR   Proteomes; UP000001734; Chromosome.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.3290; -; 1.
DR   InterPro; IPR016514; EcpA.
DR   InterPro; IPR038478; Fimbrillin_EcpA_sf.
DR   Pfam; PF16449; MatB; 1.
DR   PIRSF; PIRSF007320; Fimbrillin_MatB; 1.
PE   3: Inferred from homology;
KW   Fimbrium; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..195
FT                   /note="Common pilus major fimbrillin subunit EcpA"
FT                   /id="PRO_0000367932"
SQ   SEQUENCE   195 AA;  19971 MW;  5CABC0069CA0DF2D CRC64;
     MKKKVLAIAL VTAFTGMGVA QAADVTAQAV ATWSATAKKD TTSKLVVTPL GSLAFQYAEG
     IKGFNSQKGL FDVAIEGDAT ATAFKLTSRL ITNTLTQLDT SGSTLSVGVD YNGAAVEKTA
     DTVMIDTANG VLGGNLSALA NGYNASGRTT AQDGFTFSII SGTTNGTTAV TDYSTLPEGI
     WSGDVSVQFD ATWTS