ID   ECPA_SHIBS              Reviewed;         211 AA.
AC   Q325R4;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Common pilus major fimbrillin subunit EcpA;
DE   AltName: Full=MatB fimbrillin;
DE   Flags: Precursor;
GN   Name=ecpA; Synonyms=matB; OrderedLocusNames=SBO_0226;
OS   Shigella boydii serotype 4 (strain Sb227).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=300268;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sb227;
RX   PubMed=16275786; DOI=10.1093/nar/gki954;
RA   Yang F., Yang J., Zhang X., Chen L., Jiang Y., Yan Y., Tang X., Wang J.,
RA   Xiong Z., Dong J., Xue Y., Zhu Y., Xu X., Sun L., Chen S., Nie H., Peng J.,
RA   Xu J., Wang Y., Yuan Z., Wen Y., Yao Z., Shen Y., Qiang B., Hou Y., Yu J.,
RA   Jin Q.;
RT   "Genome dynamics and diversity of Shigella species, the etiologic agents of
RT   bacillary dysentery.";
RL   Nucleic Acids Res. 33:6445-6458(2005).
CC   -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli common
CC       pilus (ECP). ECP plays a dual role in early-stage biofilm development
CC       and host cell recognition. Major subunit of the fimbria (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Self-associates. Forms filaments. Interacts with EcpD (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000250}.
CC   -!- INDUCTION: Positively regulated by EcpR. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EcpA/MatB fimbrillin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000036; ABB64944.1; -; Genomic_DNA.
DR   RefSeq; WP_000150121.1; NC_007613.1.
DR   AlphaFoldDB; Q325R4; -.
DR   SMR; Q325R4; -.
DR   EnsemblBacteria; ABB64944; ABB64944; SBO_0226.
DR   KEGG; sbo:SBO_0226; -.
DR   HOGENOM; CLU_120328_0_0_6; -.
DR   OMA; AQDQFTF; -.
DR   Proteomes; UP000007067; Chromosome.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.3290; -; 1.
DR   InterPro; IPR016514; EcpA.
DR   InterPro; IPR038478; Fimbrillin_EcpA_sf.
DR   Pfam; PF16449; MatB; 1.
DR   PIRSF; PIRSF007320; Fimbrillin_MatB; 1.
PE   3: Inferred from homology;
KW   Fimbrium; Signal.
FT   SIGNAL          1..38
FT                   /evidence="ECO:0000255"
FT   CHAIN           39..211
FT                   /note="Common pilus major fimbrillin subunit EcpA"
FT                   /id="PRO_0000367934"
SQ   SEQUENCE   211 AA;  21915 MW;  CD9841A46C1BB79F CRC64;
     MTHWDITSSI QLGKKCNEKK VLAIALVTVF TGMGVAQAAD VTAQAVATWS ATAKKDTTSN
     LVVTSLGSLA FQYAEGIKGF NSQKGLFDVA IEGDSTATAF KLTSRLITNT LTQLDTSGST
     LNVGVDYNGA AVEKTGDTVM IDTANGVLGG NLSPLANGYN ASNRTTAQDG FTFTIISGTT
     NGTTAVTDYS TLPEGIWSGD VSVQFDATWT S