ID   ECPC_ECO27              Reviewed;         841 AA.
AC   B7UJD9;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Probable outer membrane usher protein EcpC;
DE   Flags: Precursor;
GN   Name=ecpC; OrderedLocusNames=E2348C_0247;
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC;
RX   PubMed=18952797; DOI=10.1128/jb.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T., Henderson I.R.,
RA   Harris D., Asadulghani M., Kurokawa K., Dean P., Kenny B., Quail M.A.,
RA   Thurston S., Dougan G., Hayashi T., Parkhill J., Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
RN   [2]
RP   INDUCTION.
RC   STRAIN=E2348/69 / EPEC;
RX   PubMed=22797761; DOI=10.1128/jb.00915-12;
RA   Martinez-Santos V.I., Medrano-Lopez A., Saldana Z., Giron J.A.,
RA   Puente J.L.;
RT   "Transcriptional regulation of the ecp operon by EcpR, IHF, and H-NS in
RT   attaching and effacing Escherichia coli.";
RL   J. Bacteriol. 194:5020-5033(2012).
CC   -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli common
CC       pilus (ECP). ECP is found in both commensal and pathogenic strains and
CC       plays a dual role in early-stage biofilm development and host cell
CC       recognition (By similarity). {ECO:0000250}.
CC   -!- INDUCTION: Negatively regulated by H-NS. Positively regulated by IHF
CC       and EcpR. {ECO:0000269|PubMed:22797761}.
CC   -!- SIMILARITY: Belongs to the EcpC/MatD family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FM180568; CAS07795.1; -; Genomic_DNA.
DR   RefSeq; WP_001131110.1; NC_011601.1.
DR   AlphaFoldDB; B7UJD9; -.
DR   EnsemblBacteria; CAS07795; CAS07795; E2348C_0247.
DR   KEGG; ecg:E2348C_0247; -.
DR   HOGENOM; CLU_017537_0_0_6; -.
DR   OMA; AHNRAIG; -.
DR   Proteomes; UP000008205; Chromosome.
DR   InterPro; IPR008969; CarboxyPept-like_regulatory.
DR   InterPro; IPR031917; Pilus_assem_C.
DR   InterPro; IPR032636; Pilus_assem_E-set-like_dom.
DR   Pfam; PF15976; CooC_C; 1.
DR   Pfam; PF16967; TcfC; 1.
DR   SUPFAM; SSF49464; SSF49464; 1.
PE   2: Evidence at transcript level;
KW   Fimbrium biogenesis; Signal; Transport.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..841
FT                   /note="Probable outer membrane usher protein EcpC"
FT                   /id="PRO_0000429530"
SQ   SEQUENCE   841 AA;  91365 MW;  44B629BA30F32359 CRC64;
     MPLRRFSPGL KAQFAFGMVF LFVQPDASAA DISAQQIGGV IIPQAFSQAL QDGMSVPLYI
     HLAGSQGRQD DQRIGSAFIW LDDGQLRIRK IQLEESEDNA SVSEQTRQQL MTLANAPFNE
     ALTIPLTDNA QLDLSLRQLL LQLVVKREAL GTVLRSRSED IGQSSVNTLS SNLSYNFGVY
     NNQLRNGGSN TSSYLSLNNV TALREHHVVL DGSLYGIGSG QQDSELYKAM YERDFAGHRF
     AGGMLDTWNL QSLGPMTAIS AGKIYGLSWG NQASSTIFDS SQSATPVIAF LPAAGEVHLT
     RDGRLLSVQN FTMGNHEVDT RGLPYGIYDV EVEVIVNGRV ISKRTQRVNK LFSRGRGVGA
     PLAWQIWGGS FHMDRWSENG KKTRPAKESW LAGASTSGSL STFSWAATGY GYDNQAVGET
     RLTLPLGVAI NVNLQNMLAS DSSWSNIASI SATLPGGFSS LWVNQEKTRI GNQLRRSDAD
     NRAIGGTLNL NSLWSKLGTF SISYNDDRRY NSHYYTADYY QSVYSGTFGS LGLRAGIQRY
     NNGDSSANTG KYIALDLSLP LGNWFSAGMT HQNGYTMANL SARKQFDEGT IRTVGANLSR
     AISGDTGDDK TLSGGAYAQF DARYASGTLN VNSAADGYIN TNLTANGSVG WQGKNIAASG
     RTDGNAGVIF DTGLENDGQI SAKINGRIFP LNGKRNYLPL SPYGRYEVEL QNSKNSLDSY
     DIVSGRKSHL TLYPGNVAVI EPEVKQMVTV SGRIRAEDGT LLANARINNH IGRTRTDENG
     EFVMDVDKKY PTIDFRYSGN KTCEVALELN QARGAVWVGD VVCSGLSSWA AVTQTGEENE
     S