ID   ECPC_ECO57              Reviewed;         841 AA.
AC   Q8X6I4; Q7AHC2;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Probable outer membrane usher protein EcpC;
DE   Flags: Precursor;
GN   Name=ecpC; Synonyms=yagX; OrderedLocusNames=Z0358, ECs0321;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [3]
RP   INDUCTION.
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=22797761; DOI=10.1128/jb.00915-12;
RA   Martinez-Santos V.I., Medrano-Lopez A., Saldana Z., Giron J.A.,
RA   Puente J.L.;
RT   "Transcriptional regulation of the ecp operon by EcpR, IHF, and H-NS in
RT   attaching and effacing Escherichia coli.";
RL   J. Bacteriol. 194:5020-5033(2012).
CC   -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli common
CC       pilus (ECP). ECP is found in both commensal and pathogenic strains and
CC       plays a dual role in early-stage biofilm development and host cell
CC       recognition (By similarity). {ECO:0000250}.
CC   -!- INDUCTION: Negatively regulated by H-NS. Positively regulated by IHF
CC       and EcpR. {ECO:0000269|PubMed:22797761}.
CC   -!- SIMILARITY: Belongs to the EcpC/MatD family. {ECO:0000305}.
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DR   EMBL; AE005174; AAG54616.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33744.1; -; Genomic_DNA.
DR   PIR; A90669; A90669.
DR   PIR; D85519; D85519.
DR   RefSeq; NP_308348.1; NC_002695.1.
DR   RefSeq; WP_001131063.1; NZ_SEKU01000045.1.
DR   AlphaFoldDB; Q8X6I4; -.
DR   SMR; Q8X6I4; -.
DR   STRING; 155864.EDL933_0322; -.
DR   EnsemblBacteria; AAG54616; AAG54616; Z0358.
DR   EnsemblBacteria; BAB33744; BAB33744; ECs_0321.
DR   GeneID; 914420; -.
DR   KEGG; ece:Z0358; -.
DR   KEGG; ecs:ECs_0321; -.
DR   PATRIC; fig|386585.9.peg.415; -.
DR   eggNOG; COG3188; Bacteria.
DR   HOGENOM; CLU_017537_0_0_6; -.
DR   OMA; AHNRAIG; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   InterPro; IPR008969; CarboxyPept-like_regulatory.
DR   InterPro; IPR031917; Pilus_assem_C.
DR   InterPro; IPR032636; Pilus_assem_E-set-like_dom.
DR   Pfam; PF15976; CooC_C; 1.
DR   Pfam; PF16967; TcfC; 1.
DR   SUPFAM; SSF49464; SSF49464; 1.
PE   2: Evidence at transcript level;
KW   Fimbrium biogenesis; Reference proteome; Signal; Transport.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..841
FT                   /note="Probable outer membrane usher protein EcpC"
FT                   /id="PRO_0000429531"
SQ   SEQUENCE   841 AA;  91227 MW;  DCCB0ACA1CB821E5 CRC64;
     MPLRRFSPGL KAQFAFGMVF LFVQPDASAA DISAQQIGGV IIPQAFSQAL QDGMSVPLYI
     HLAGSQGRQD DQRIGSAFIW LDDGQLRIRK IQLEESEDNA SVSEQTRQQL MALANAPFNE
     ALTIPLTDNA QLDLSLRQLL LQLVVKREAL GTVLRSRSED IGQSSVNTLS SNLSYNFGIY
     NNQLRNGGSN TSSYLSLNNV TALREHHVVL DGSLYGIGSG QQDSELYKAM YERDFAGHRF
     AGGTLDTWNL QSLGPMTAIS AGKIYGLSWG NQASSTIFDS SQSATPVIAF LPAAGEVHLT
     RDGRLLSVQN FTMGNHEVDT RGLPYGIYDV EVEVIVNGRV ISKRTQRVNK LFSRGRGVGA
     PLAWQVWGGS FHMDRWSENG KKTRPAKESW LAGASTSGSL STLSWAATGY GYDNQAVGET
     RLTLPLGGAI NVNLQNMLAS DSSWSSIGSI SATLPGGFSS LWVNQEKTRI GNQLRRSDAD
     NRAIGGTLNL NSLWSKLGTF SISYNDDRRY NSHYYTADYY QNVYSGTFGS LGLRAGIQRY
     NNGDSNANTG KYIALDLSLP LGNWFSAGMT HQNGYTMANL SARKQFDEGT IRTVGANLSR
     AISGDTGDDK TLSGGAYAQF DARYASGTLN VNSAADGYVN TNLTANGSVG WQGKNIAASG
     RTDGNAGVIF NTGLEDDGQI SAKINGRIFP LNGKRNYLPL SPYGRYEVEL QNSKNSLDSY
     DIVSGRKSHL TLYPGNVAVI EPEVKQMVTV SGRIRAEDGT LLANARINNH IGRTRTDENG
     EFVMDVDKKY PTIDFRYSGN KTCEVALELN QARGAVWVGD VVCSGLSSWA AVTQTGEENE
     S