ID   ECPC_ECOKI              Reviewed;         841 AA.
AC   D5CVJ8; D7RNS4;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Probable outer membrane usher protein EcpC;
DE   AltName: Full=Meningitis associated and temperature regulated protein D;
DE   Flags: Precursor;
GN   Name=ecpC; Synonyms=matD; OrderedLocusNames=ECOK1_0278;
OS   Escherichia coli O18:K1:H7 (strain IHE3034 / ExPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=714962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=IHE3034 / ExPEC;
RX   PubMed=20522494; DOI=10.1099/mic.0.039610-0;
RA   Lehti T.A., Bauchart P., Heikkinen J., Hacker J., Korhonen T.K.,
RA   Dobrindt U., Westerlund-Wikstrom B.;
RT   "Mat fimbriae promote biofilm formation by meningitis-associated
RT   Escherichia coli.";
RL   Microbiology 156:2408-2417(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IHE3034 / ExPEC;
RX   PubMed=20439758; DOI=10.1073/pnas.0915077107;
RA   Moriel D.G., Bertoldi I., Spagnuolo A., Marchi S., Rosini R., Nesta B.,
RA   Pastorello I., Corea V.A., Torricelli G., Cartocci E., Savino S.,
RA   Scarselli M., Dobrindt U., Hacker J., Tettelin H., Tallon L.J.,
RA   Sullivan S., Wieler L.H., Ewers C., Pickard D., Dougan G., Fontana M.R.,
RA   Rappuoli R., Pizza M., Serino L.;
RT   "Identification of protective and broadly conserved vaccine antigens from
RT   the genome of extraintestinal pathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:9072-9077(2010).
CC   -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli common
CC       pilus (ECP). ECP is found in both commensal and pathogenic strains and
CC       plays a dual role in early-stage biofilm development and host cell
CC       recognition. {ECO:0000269|PubMed:20522494}.
CC   -!- INDUCTION: Negatively regulated by H-NS. Positively regulated by IHF
CC       and EcpR (By similarity). {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: Mutants do not express ECP and are defective in
CC       biofilm formation. {ECO:0000269|PubMed:20522494}.
CC   -!- SIMILARITY: Belongs to the EcpC/MatD family. {ECO:0000305}.
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DR   EMBL; HM102365; ADI59490.1; -; Genomic_DNA.
DR   EMBL; CP001969; ADE88558.1; -; Genomic_DNA.
DR   RefSeq; WP_001131109.1; NC_017628.1.
DR   AlphaFoldDB; D5CVJ8; -.
DR   KEGG; eih:ECOK1_0278; -.
DR   PATRIC; fig|714962.3.peg.278; -.
DR   HOGENOM; CLU_017537_0_0_6; -.
DR   OMA; AHNRAIG; -.
DR   InterPro; IPR008969; CarboxyPept-like_regulatory.
DR   InterPro; IPR031917; Pilus_assem_C.
DR   InterPro; IPR032636; Pilus_assem_E-set-like_dom.
DR   Pfam; PF15976; CooC_C; 1.
DR   Pfam; PF16967; TcfC; 1.
DR   SUPFAM; SSF49464; SSF49464; 1.
PE   3: Inferred from homology;
KW   Fimbrium biogenesis; Signal; Transport.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..841
FT                   /note="Probable outer membrane usher protein EcpC"
FT                   /id="PRO_0000429532"
SQ   SEQUENCE   841 AA;  91323 MW;  34746D6FC5F828EB CRC64;
     MPLRRFSPGL KAQFAFGMVF LFVQPDASAA DISAQQIGGV IIPQAFSQAL QDGMSVPLYI
     HLAGSQGRQD DQRIGSAFIW LDDGQLRIRK IQLEESEDNA SVSEQTRQQL MTLANAPFNE
     ALTIPLTDNA QLDLSLRQLL LQLVVKREAL GTVLRSRSED IGQSSVNTLS SNLSYNFGVY
     NNQLRNGGSN TSSYLSLNNV TALREHHVVL DGSLYGIGSG QQDSELYKAM YERDFAGHRF
     AGGMLDTWNL QSLGPMTAIS AGKIYGLSWG NQASSTIFDS SQSATPVIAF LPAAGEVHLT
     RDGRLLSVQN FTMGNHEVDT RGLPYGIYDV EVEVIVNGRV ISKRTQRVNK LFSRGRGVGA
     PLAWQIWGGS FHMDRWSENG KKTRPAKESW LAGASTSGSL STFSWAATGY GYDNQAVGET
     RLTLPLGGAI NVNLQNMLAS DSSWSNIASI SATLPGGFSS LWVNQEKTRI GNQLRRSDAD
     NRAIGGTLNL NSLWSKLGTF SISYNDDRRY NSHYYTADYY QSVYSGTFGS LGLRAGIQRY
     NNGDSSANTG KYIALDLSLP LGNWFSAGMT HQNGYTMANL SARKQFDEGT IRTVGANLSR
     AISGDTGDDK TLSGGAYAQF DARYASGTLN VNSAADGYIN TNLTANGSVG WQGKNIAASG
     RTDGNAGVIF DTGLENDGQI SAKINGRIFP LNGKRNYLPL SPYGRYEVEL QNSKNSLDSY
     DIVSGRKSHL TLYPGNVAVI EPEVKQMVTV SGRIRAEDGT LLANARINNH IGRTRTDENG
     EFVMDVDKKY PTIDFRYSGN KTCEVALELN QARGAVWVGD VVCSGLSSWA AVTQTGEENE
     S