ID   ECPC_ECOLI              Reviewed;         841 AA.
AC   P77802; Q2MCD1;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Probable outer membrane usher protein EcpC;
DE   Flags: Precursor;
GN   Name=ecpC; Synonyms=matD, yagX; OrderedLocusNames=b0291, JW0285;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RA   Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA   Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA   Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT   "Sequence of minutes 4-25 of Escherichia coli.";
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   EXPRESSION.
RC   STRAIN=K12;
RX   PubMed=20522494; DOI=10.1099/mic.0.039610-0;
RA   Lehti T.A., Bauchart P., Heikkinen J., Hacker J., Korhonen T.K.,
RA   Dobrindt U., Westerlund-Wikstrom B.;
RT   "Mat fimbriae promote biofilm formation by meningitis-associated
RT   Escherichia coli.";
RL   Microbiology 156:2408-2417(2010).
CC   -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli common
CC       pilus (ECP). ECP is found in both commensal and pathogenic strains and
CC       plays a dual role in early-stage biofilm development and host cell
CC       recognition (By similarity). {ECO:0000250}.
CC   -!- INTERACTION:
CC       P77802; P76594: patZ; NbExp=4; IntAct=EBI-561348, EBI-557388;
CC   -!- INDUCTION: Negatively regulated by H-NS. Positively regulated by IHF
CC       and EcpR (By similarity). {ECO:0000250}.
CC   -!- MISCELLANEOUS: Not expressed under classical laboratory conditions, but
CC       is functional when constitutively expressed.
CC       {ECO:0000305|PubMed:20522494}.
CC   -!- SIMILARITY: Belongs to the EcpC/MatD family. {ECO:0000305}.
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DR   EMBL; U73857; AAB18020.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC73394.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76075.1; -; Genomic_DNA.
DR   PIR; C64755; C64755.
DR   RefSeq; NP_414825.1; NC_000913.3.
DR   RefSeq; WP_001131096.1; NZ_SSZK01000048.1.
DR   AlphaFoldDB; P77802; -.
DR   BioGRID; 4259790; 217.
DR   BioGRID; 851922; 1.
DR   DIP; DIP-11250N; -.
DR   IntAct; P77802; 2.
DR   STRING; 511145.b0291; -.
DR   PaxDb; P77802; -.
DR   PRIDE; P77802; -.
DR   EnsemblBacteria; AAC73394; AAC73394; b0291.
DR   EnsemblBacteria; BAE76075; BAE76075; BAE76075.
DR   GeneID; 947606; -.
DR   KEGG; ecj:JW0285; -.
DR   KEGG; eco:b0291; -.
DR   PATRIC; fig|1411691.4.peg.1987; -.
DR   EchoBASE; EB3333; -.
DR   eggNOG; COG3188; Bacteria.
DR   HOGENOM; CLU_017537_0_0_6; -.
DR   OMA; AHNRAIG; -.
DR   BioCyc; EcoCyc:G6162-MON; -.
DR   PRO; PR:P77802; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   InterPro; IPR008969; CarboxyPept-like_regulatory.
DR   InterPro; IPR031917; Pilus_assem_C.
DR   InterPro; IPR032636; Pilus_assem_E-set-like_dom.
DR   Pfam; PF15976; CooC_C; 1.
DR   Pfam; PF16967; TcfC; 1.
DR   SUPFAM; SSF49464; SSF49464; 1.
PE   1: Evidence at protein level;
KW   Fimbrium biogenesis; Reference proteome; Signal; Transport.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..841
FT                   /note="Probable outer membrane usher protein EcpC"
FT                   /id="PRO_0000013788"
SQ   SEQUENCE   841 AA;  91229 MW;  D2016BB0ACD726AC CRC64;
     MPLRRFSPGL KAQFAFGMVF LFVQPDASAA DISAQQIGGV IIPQAFSQAL QDGMSVPLYI
     HLAGSQGRQD DQRIGSAFIW LDDGQLRIRK IQLEESEDNA SVSEQTRQQL MALANAPFNE
     ALTIPLTDNA QLDLSLRQLL LQLVVKREAL GTVLRSRSED IGQSSVNTLS SNLSYNLGVY
     NNQLRNGGSN TSSYLSLNNV TALREHHVVL DGSLYGIGSG QQDSELYKAM YERDFAGHRF
     AGGMLDTWNL QSLGPMTAIS AGKIYGLSWG NQASSTIFDS SQSATPVIAF LPAAGEVHLT
     RDGRLLSVQN FTMGNHEVDT RGLPYGIYDV EVEVIVNGRV ISKRTQRVNK LFSRGRGVGA
     PLAWQVWGGS FHMDRWSENG KKTRPAKESW LAGASTSGSL STLSWAATGY GYDNQAVGET
     RLTLPLGGAI NVNLQNMLAS DSSWSSIGSI SATLPGGFSS LWVNQEKTRI GNQLRRSDAD
     NRAIGGTLNL NSLWSKLGTF SISYNDDRRY NSHYYTADYY QNVYSGTFGS LGLRAGIQRY
     NNGDSNANTG KYIALDLSLP LGNWFSAGMT HQNGYTMANL SARKQFDEGT IRTVGANLSR
     AISGDTGDDK TLSGGAYAQF DARYASGTLN VNSAADGYVN TNLTANGSVG WQGKNIAASG
     RTDGNAGVIF NTGLEDDGQI SAKINGRIFP LNGKRNYLPL SPYGRYEVEL QNSKNSLDSY
     DIVSGRKSRL TLYPGNVAVI EPEVKQMVTV SGRIRAEDGT LLANARINNH IGRTRTDENG
     EFVMDVDKKY PTIDFRYSGN KTCEVALELN QARGAVWVGD VVCSGLSSWA AVTQTGEENE
     S