ID   ECPD_ECO57              Reviewed;         547 AA.
AC   Q8X4N4; Q7AHC3;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Fimbria adhesin EcpD;
DE   Flags: Precursor;
GN   Name=ecpD; Synonyms=yagW; OrderedLocusNames=Z0357, ECs0320;
OS   Escherichia coli O157:H7.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83334;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
RX   PubMed=11258796; DOI=10.1093/dnares/8.1.11;
RA   Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
RA   Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T., Iida T.,
RA   Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T., Kuhara S.,
RA   Shiba T., Hattori M., Shinagawa H.;
RT   "Complete genome sequence of enterohemorrhagic Escherichia coli O157:H7 and
RT   genomic comparison with a laboratory strain K-12.";
RL   DNA Res. 8:11-22(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=11206551; DOI=10.1038/35054089;
RA   Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D., Rose D.J.,
RA   Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., Posfai G.,
RA   Hackett J., Klink S., Boutin A., Shao Y., Miller L., Grotbeck E.J.,
RA   Davis N.W., Lim A., Dimalanta E.T., Potamousis K., Apodaca J.,
RA   Anantharaman T.S., Lin J., Yen G., Schwartz D.C., Welch R.A.,
RA   Blattner F.R.;
RT   "Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
RL   Nature 409:529-533(2001).
RN   [3]
RP   INDUCTION.
RC   STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
RX   PubMed=22797761; DOI=10.1128/jb.00915-12;
RA   Martinez-Santos V.I., Medrano-Lopez A., Saldana Z., Giron J.A.,
RA   Puente J.L.;
RT   "Transcriptional regulation of the ecp operon by EcpR, IHF, and H-NS in
RT   attaching and effacing Escherichia coli.";
RL   J. Bacteriol. 194:5020-5033(2012).
CC   -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli common
CC       pilus (ECP). ECP is found in both commensal and pathogenic strains and
CC       plays a dual role in early-stage biofilm development and host cell
CC       recognition. Tip pilus adhesin, which is required for assembly of EcpA
CC       into fibers (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms polymers. Interacts with EcpA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000250}.
CC   -!- INDUCTION: Negatively regulated by H-NS. Positively regulated by IHF
CC       and EcpR. {ECO:0000269|PubMed:22797761}.
CC   -!- SIMILARITY: Belongs to the EcpD/MatE family. {ECO:0000305}.
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DR   EMBL; AE005174; AAG54615.1; -; Genomic_DNA.
DR   EMBL; BA000007; BAB33743.1; -; Genomic_DNA.
DR   PIR; C85519; C85519.
DR   PIR; H90668; H90668.
DR   RefSeq; NP_308347.1; NC_002695.1.
DR   RefSeq; WP_001265657.1; NZ_SWKA01000005.1.
DR   AlphaFoldDB; Q8X4N4; -.
DR   STRING; 155864.EDL933_0321; -.
DR   EnsemblBacteria; AAG54615; AAG54615; Z0357.
DR   EnsemblBacteria; BAB33743; BAB33743; ECs_0320.
DR   GeneID; 914419; -.
DR   KEGG; ece:Z0357; -.
DR   KEGG; ecs:ECs_0320; -.
DR   PATRIC; fig|386585.9.peg.414; -.
DR   eggNOG; ENOG502Z8ZC; Bacteria.
DR   HOGENOM; CLU_039494_0_0_6; -.
DR   OMA; NADCQTQ; -.
DR   Proteomes; UP000000558; Chromosome.
DR   Proteomes; UP000002519; Chromosome.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
PE   2: Evidence at transcript level;
KW   Fimbrium; Receptor; Reference proteome; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..547
FT                   /note="Fimbria adhesin EcpD"
FT                   /id="PRO_0000429535"
SQ   SEQUENCE   547 AA;  60007 MW;  C38EB4EDE4E8C08E CRC64;
     MRVNLLIAMI IFALIWPVTA LRAAVSKTTW ADAPAREFVF VENNSDDNFF VTPGGALDPR
     LTGANRWTGL KYNGSGTIYQ QSLGYIDNGY NTGLYTNWKF DMWLENSPVS SPLTGLRCIN
     WYAGCNMTTS LILPQTTDTS GFYGATVTSG GAKWMHGMLS DAFYQYLQQM PVGSSFTMTI
     NACQTSVNYD ASSGARCKDQ ASGNWYVRNV THTKAANLRL INTHSLAEVF INSDGVPTLG
     EGNADCRTQT IGSRSGLSCK MVNYTLQTNG LSNTSIHIFP AIANSSLASA VGAYDMQFSL
     NGSSWKPVSN TAYYYTFNEM KSADSIYVFF SSNFFKQMVN QGISDINTKD LFNFRFQNTT
     SPESGWYEFS TSNTLIIKPR DFSISIISDE YTQTPSREGY VGSGESALDF GYIVTTSGKT
     AADEVLIKVT GPAQVIGGRS YCVFSSDDGK AKVPFPATLS FITRNGATKT YDAGCDDSWR
     DMTDALWLTT PWTDISGEVG QMDKTTVKFS IPMDNAISLR TVDDNGWFGE VSASGEIHVQ
     ATWRNIN