ID   ECPD_ECOKI              Reviewed;         547 AA.
AC   D5CVJ7; D7RNS5;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Fimbria adhesin EcpD;
DE   AltName: Full=Meningitis associated and temperature regulated protein E;
DE   Flags: Precursor;
GN   Name=ecpD; Synonyms=matE; OrderedLocusNames=ECOK1_0277;
OS   Escherichia coli O18:K1:H7 (strain IHE3034 / ExPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=714962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=IHE3034 / ExPEC;
RX   PubMed=20522494; DOI=10.1099/mic.0.039610-0;
RA   Lehti T.A., Bauchart P., Heikkinen J., Hacker J., Korhonen T.K.,
RA   Dobrindt U., Westerlund-Wikstrom B.;
RT   "Mat fimbriae promote biofilm formation by meningitis-associated
RT   Escherichia coli.";
RL   Microbiology 156:2408-2417(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IHE3034 / ExPEC;
RX   PubMed=20439758; DOI=10.1073/pnas.0915077107;
RA   Moriel D.G., Bertoldi I., Spagnuolo A., Marchi S., Rosini R., Nesta B.,
RA   Pastorello I., Corea V.A., Torricelli G., Cartocci E., Savino S.,
RA   Scarselli M., Dobrindt U., Hacker J., Tettelin H., Tallon L.J.,
RA   Sullivan S., Wieler L.H., Ewers C., Pickard D., Dougan G., Fontana M.R.,
RA   Rappuoli R., Pizza M., Serino L.;
RT   "Identification of protective and broadly conserved vaccine antigens from
RT   the genome of extraintestinal pathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:9072-9077(2010).
CC   -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli common
CC       pilus (ECP). ECP is found in both commensal and pathogenic strains and
CC       plays a dual role in early-stage biofilm development and host cell
CC       recognition. Tip pilus adhesin, which is required for assembly of EcpA
CC       into fibers (Probable). {ECO:0000305|PubMed:20522494}.
CC   -!- SUBUNIT: Forms polymers. Interacts with EcpA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000250}.
CC   -!- INDUCTION: Negatively regulated by H-NS. Positively regulated by IHF
CC       and EcpR (By similarity). {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: Mutants do not express ECP and are defective in
CC       biofilm formation. {ECO:0000269|PubMed:20522494}.
CC   -!- SIMILARITY: Belongs to the EcpD/MatE family. {ECO:0000305}.
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DR   EMBL; HM102365; ADI59491.1; -; Genomic_DNA.
DR   EMBL; CP001969; ADE92637.1; -; Genomic_DNA.
DR   RefSeq; WP_001265640.1; NC_017628.1.
DR   AlphaFoldDB; D5CVJ7; -.
DR   KEGG; eih:ECOK1_0277; -.
DR   PATRIC; fig|714962.3.peg.277; -.
DR   HOGENOM; CLU_039494_0_0_6; -.
DR   OMA; NADCQTQ; -.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Fimbrium; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..547
FT                   /note="Fimbria adhesin EcpD"
FT                   /id="PRO_0000429536"
SQ   SEQUENCE   547 AA;  59961 MW;  FE826A43B232F41E CRC64;
     MRVNLLIAMI IFALIWPATA LRAAVSKTTW ADAPAREFVF VENNSDDNFF VTPGGALDPR
     LTGANRWTGL KYNGSGTIYQ QSLGYIDNGY NTGLYTNWKF DMWLENSPVS SPLTGLRCIN
     WYAGCNMTTS LILPQTTDAS GFYGATVTSG GAKWMHGMLS DAFYQYLQQM PVGSSFTMTI
     NACQTSVNYD ANSGARCKDQ ASGNWYVRNV THTKAANLRL INTHSLAEVF INSDGVPTLG
     EGNADCRTQT IGSRSGLSCK MVNYTLQTNG LSNTSIHIFP AIANSSLASA VGAYDMQFSL
     NGSSWKPVSN TAYYYTFNEM KSADSIYVFF SSNFFKQMVN LGISDINTKD LFNFRFQNTT
     SPESGWYEFS TSNTLIIKPR DFSISIISDE YTQTPSREGY VGSGESALDF GYIVTTSGKT
     AADEVLIKVT GPAQVIGGRS YCVFSSDDGK AKVPFPATLS FITRNGATKT YDAGCDDSWR
     DMTDALWLTT PWTDISGEVG QMDKTTVKFS IPMDNAISLR TVDDNGWFGE VSASGEIHVQ
     ATWRNIN