ID   ECPD_ECOL6              Reviewed;         547 AA.
AC   Q8FKL3;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Fimbria adhesin EcpD;
DE   Flags: Precursor;
GN   Name=ecpD; Synonyms=yagW; OrderedLocusNames=c0401;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 21-37, AND INTERACTION WITH ECPA.
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=22355107; DOI=10.1073/pnas.1106733109;
RA   Garnett J.A., Martinez-Santos V.I., Saldana Z., Pape T., Hawthorne W.,
RA   Chan J., Simpson P.J., Cota E., Puente J.L., Giron J.A., Matthews S.;
RT   "Structural insights into the biogenesis and biofilm formation by the
RT   Escherichia coli common pilus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:3950-3955(2012).
CC   -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli common
CC       pilus (ECP). ECP is found in both commensal and pathogenic strains and
CC       plays a dual role in early-stage biofilm development and host cell
CC       recognition. Tip pilus adhesin, which is required for assembly of EcpA
CC       into fibers (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms polymers (By similarity). Interacts with EcpA.
CC       {ECO:0000250, ECO:0000269|PubMed:22355107}.
CC   -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000250}.
CC   -!- INDUCTION: Negatively regulated by H-NS. Positively regulated by IHF
CC       and EcpR (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EcpD/MatE family. {ECO:0000305}.
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DR   EMBL; AE014075; AAN78882.1; -; Genomic_DNA.
DR   RefSeq; WP_001265646.1; NC_004431.1.
DR   PDB; 3QS3; X-ray; 2.10 A; A/B/C/D/E/F/G/H/I/J/K/L=21-37.
DR   PDBsum; 3QS3; -.
DR   AlphaFoldDB; Q8FKL3; -.
DR   SMR; Q8FKL3; -.
DR   STRING; 199310.c0401; -.
DR   EnsemblBacteria; AAN78882; AAN78882; c0401.
DR   KEGG; ecc:c0401; -.
DR   eggNOG; ENOG502Z8ZC; Bacteria.
DR   HOGENOM; CLU_039494_0_0_6; -.
DR   OMA; NADCQTQ; -.
DR   BioCyc; ECOL199310:C0401-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
PE   1: Evidence at protein level;
KW   3D-structure; Fimbrium; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..547
FT                   /note="Fimbria adhesin EcpD"
FT                   /id="PRO_0000429537"
FT   STRAND          22..37
FT                   /evidence="ECO:0007829|PDB:3QS3"
SQ   SEQUENCE   547 AA;  59934 MW;  7FF1EFA911BC5CF0 CRC64;
     MRVNLLIAMI IFALIWPATA LRAAVSKTTW ADAPAREFVF VENNSDDNFF VTPGGALDPR
     LTGANRWTGL KYNGSGTIYQ QSLGYIDNGY NTGLYTNWKF DMWLENSPVS SPLTGLRCIN
     WYAGCNMTTS LILPQTTDAS GFYGATVTSG GAKWMHGMLS DAFYQYLQQM PVGSSFTMTI
     NACQTSVNYD ASSGARCKDQ ASGNWYVRNV THTKAANLRL INTHSLAEVF INSDGVPTLG
     EGNADCRTQT IGSRSGLSCK MVNYTLQTNG LSNTSIHIFP AIANSSLASA VGAYDMQFSL
     NGSSWKPVSN TAYYYTFNEM KSADSIYVFF SSNFFKQMVN LGISDINTKD LFNFRFQNTT
     SPESGWYEFS TSNTLIIKPR DFSISIISDE YTQTPSREGY VGSGESALDF GYIVTTSGKT
     AADEVLIKVT GPAQVIGGRS YCVFSSDDGK AKVPFPATLS FITRNGATKT YDAGCDDSWR
     DMTDALWLTT PWTDISGEVG QMDKTTVKFS IPMDNAISLR TVDDNGWFGE VSASGEIHVQ
     ATWRNIN