ID   ECPD_ECOLI              Reviewed;         547 AA.
AC   P77694; Q2MCD2;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Fimbria adhesin EcpD;
DE   Flags: Precursor;
GN   Name=ecpD; Synonyms=matE, yagW; OrderedLocusNames=b0290, JW0284;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RA   Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA   Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA   Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT   "Sequence of minutes 4-25 of Escherichia coli.";
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   EXPRESSION.
RC   STRAIN=K12;
RX   PubMed=20522494; DOI=10.1099/mic.0.039610-0;
RA   Lehti T.A., Bauchart P., Heikkinen J., Hacker J., Korhonen T.K.,
RA   Dobrindt U., Westerlund-Wikstrom B.;
RT   "Mat fimbriae promote biofilm formation by meningitis-associated
RT   Escherichia coli.";
RL   Microbiology 156:2408-2417(2010).
CC   -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli common
CC       pilus (ECP). ECP is found in both commensal and pathogenic strains and
CC       plays a dual role in early-stage biofilm development and host cell
CC       recognition. Tip pilus adhesin, which is required for assembly of EcpA
CC       into fibers (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms polymers. Interacts with EcpA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000250}.
CC   -!- INDUCTION: Negatively regulated by H-NS. Positively regulated by IHF
CC       and EcpR (By similarity). {ECO:0000250}.
CC   -!- MISCELLANEOUS: Not expressed under classical laboratory conditions, but
CC       is functional when constitutively expressed.
CC       {ECO:0000305|PubMed:20522494}.
CC   -!- SIMILARITY: Belongs to the EcpD/MatE family. {ECO:0000305}.
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DR   EMBL; U73857; AAB18019.1; -; Genomic_DNA.
DR   EMBL; U00096; AAC73393.1; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76074.1; -; Genomic_DNA.
DR   PIR; B64755; B64755.
DR   RefSeq; NP_414824.1; NC_000913.3.
DR   RefSeq; WP_001310578.1; NZ_SSZK01000048.1.
DR   AlphaFoldDB; P77694; -.
DR   BioGRID; 4261569; 12.
DR   DIP; DIP-11249N; -.
DR   IntAct; P77694; 4.
DR   STRING; 511145.b0290; -.
DR   PaxDb; P77694; -.
DR   PRIDE; P77694; -.
DR   EnsemblBacteria; AAC73393; AAC73393; b0290.
DR   EnsemblBacteria; BAE76074; BAE76074; BAE76074.
DR   GeneID; 947349; -.
DR   KEGG; ecj:JW0284; -.
DR   KEGG; eco:b0290; -.
DR   PATRIC; fig|1411691.4.peg.1988; -.
DR   EchoBASE; EB3332; -.
DR   eggNOG; ENOG502Z8ZC; Bacteria.
DR   HOGENOM; CLU_039494_0_0_6; -.
DR   OMA; NADCQTQ; -.
DR   BioCyc; EcoCyc:G6161-MON; -.
DR   PRO; PR:P77694; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Fimbrium; Reference proteome; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..547
FT                   /note="Fimbria adhesin EcpD"
FT                   /id="PRO_0000168565"
SQ   SEQUENCE   547 AA;  59997 MW;  DF6467ECDC8785E3 CRC64;
     MRVNLLITMI IFALIWPVTA LRAAVSKTTW ADAPAREFVF VENNSDDNFF VTPGGALDPR
     LTGANRWTGL KYTGSGTIYQ QSLGYIDNGY NTGLYTNWKF DMWLENSPVS SPLTGLRCIN
     WYAGCNMTTS LILPQTTDAS GFYGATVTSG GAKWMHGMLS DAFYQYMQQM PVGSSFTMTI
     NACQTSVNYD ASSGARCKDQ ASGNWYVRNV THTKAANLRL INTHSLAEVF INSDGVPTLG
     EGNADCRTQT IGSRSGLSCK MVNYTLQTNG LSNTSIHIFP AIANSSLASA VGAYDMQFSL
     NGSSWKPVSN TAYYYTFNEM KSADSIYVFF SSNFFKQMVN LGISDINTKD LFNFRFQNTT
     SPESGWYEFS TSNTLIIKPR DFSISIISDE YTQTPSREGY VGSGESALDF GYIVTTSGKT
     AADEVLIKVT GPAQVIGGRS YCVFSSDDGK AKVPFPATLS FITRNGATKT YDAGCDDSWR
     DMTDALWLTT PWTDISGEVG QMDKTTVKFS IPMDNAISLR TVDDNGWFGE VSASGEIHVQ
     ATWRNIN