ID   ECPE_ECO27              Reviewed;         236 AA.
AC   B7UJD7;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Probable fimbrial chaperone EcpE;
DE   Flags: Precursor;
GN   Name=ecpE; OrderedLocusNames=E2348C_0245;
OS   Escherichia coli O127:H6 (strain E2348/69 / EPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=574521;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=E2348/69 / EPEC;
RX   PubMed=18952797; DOI=10.1128/jb.01238-08;
RA   Iguchi A., Thomson N.R., Ogura Y., Saunders D., Ooka T., Henderson I.R.,
RA   Harris D., Asadulghani M., Kurokawa K., Dean P., Kenny B., Quail M.A.,
RA   Thurston S., Dougan G., Hayashi T., Parkhill J., Frankel G.;
RT   "Complete genome sequence and comparative genome analysis of
RT   enteropathogenic Escherichia coli O127:H6 strain E2348/69.";
RL   J. Bacteriol. 191:347-354(2009).
RN   [2]
RP   INDUCTION.
RC   STRAIN=E2348/69 / EPEC;
RX   PubMed=22797761; DOI=10.1128/jb.00915-12;
RA   Martinez-Santos V.I., Medrano-Lopez A., Saldana Z., Giron J.A.,
RA   Puente J.L.;
RT   "Transcriptional regulation of the ecp operon by EcpR, IHF, and H-NS in
RT   attaching and effacing Escherichia coli.";
RL   J. Bacteriol. 194:5020-5033(2012).
CC   -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli common
CC       pilus (ECP). ECP is found in both commensal and pathogenic strains and
CC       plays a dual role in early-stage biofilm development and host cell
CC       recognition (By similarity). {ECO:0000250}.
CC   -!- INDUCTION: Negatively regulated by H-NS. Positively regulated by IHF
CC       and EcpR. {ECO:0000269|PubMed:22797761}.
CC   -!- SIMILARITY: Belongs to the EcpB/EcpE family. {ECO:0000305}.
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DR   EMBL; FM180568; CAS07793.1; -; Genomic_DNA.
DR   RefSeq; WP_001339257.1; NC_011601.1.
DR   AlphaFoldDB; B7UJD7; -.
DR   SMR; B7UJD7; -.
DR   PRIDE; B7UJD7; -.
DR   EnsemblBacteria; CAS07793; CAS07793; E2348C_0245.
DR   KEGG; ecg:E2348C_0245; -.
DR   HOGENOM; CLU_106652_0_0_6; -.
DR   OMA; RPREVQF; -.
DR   Proteomes; UP000008205; Chromosome.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR008962; PapD-like_sf.
DR   SUPFAM; SSF49354; SSF49354; 1.
PE   2: Evidence at transcript level;
KW   Chaperone; Fimbrium biogenesis; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..236
FT                   /note="Probable fimbrial chaperone EcpE"
FT                   /id="PRO_0000429538"
SQ   SEQUENCE   236 AA;  26634 MW;  C254A7B2DCC24FA1 CRC64;
     MFRRRGVTLT KALLTVVCML AAPLTQAISV GNLTFSLPSE TDFVSKRVVN NNKSARIYRI
     AISAIDSPGS SELRTRPVDG ELLFAPRQLA LQAGESEYFK FYYHGPRDNR ERYYRVSFRE
     VPTRNLTKRS PTGGEVSTEP VVVMDTILVV RPRQVQFKWS FDQVTGTVSN TGNTWFKLLI
     KPGCDSTEEE GDAWYLRPGD VVHQPELRQP GNHYLVYNDK FIKISDSCPA KPPSAD