ID   ECPE_ECOKI              Reviewed;         236 AA.
AC   D5CVJ6;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   15-JUN-2010, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Probable fimbrial chaperone EcpE;
DE   AltName: Full=Meningitis associated and temperature regulated protein F;
DE   Flags: Precursor;
GN   Name=ecpE; Synonyms=matF; OrderedLocusNames=ECOK1_0276;
OS   Escherichia coli O18:K1:H7 (strain IHE3034 / ExPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=714962;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IHE3034 / ExPEC;
RX   PubMed=20439758; DOI=10.1073/pnas.0915077107;
RA   Moriel D.G., Bertoldi I., Spagnuolo A., Marchi S., Rosini R., Nesta B.,
RA   Pastorello I., Corea V.A., Torricelli G., Cartocci E., Savino S.,
RA   Scarselli M., Dobrindt U., Hacker J., Tettelin H., Tallon L.J.,
RA   Sullivan S., Wieler L.H., Ewers C., Pickard D., Dougan G., Fontana M.R.,
RA   Rappuoli R., Pizza M., Serino L.;
RT   "Identification of protective and broadly conserved vaccine antigens from
RT   the genome of extraintestinal pathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:9072-9077(2010).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=IHE3034 / ExPEC;
RX   PubMed=20522494; DOI=10.1099/mic.0.039610-0;
RA   Lehti T.A., Bauchart P., Heikkinen J., Hacker J., Korhonen T.K.,
RA   Dobrindt U., Westerlund-Wikstrom B.;
RT   "Mat fimbriae promote biofilm formation by meningitis-associated
RT   Escherichia coli.";
RL   Microbiology 156:2408-2417(2010).
CC   -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli common
CC       pilus (ECP). ECP is found in both commensal and pathogenic strains and
CC       plays a dual role in early-stage biofilm development and host cell
CC       recognition. {ECO:0000269|PubMed:20522494}.
CC   -!- INDUCTION: Negatively regulated by H-NS. Positively regulated by IHF
CC       and EcpR (By similarity). {ECO:0000250}.
CC   -!- DISRUPTION PHENOTYPE: Mutants do not express ECP and are defective in
CC       biofilm formation. {ECO:0000269|PubMed:20522494}.
CC   -!- SIMILARITY: Belongs to the EcpB/EcpE family. {ECO:0000305}.
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DR   EMBL; CP001969; ADE89015.1; -; Genomic_DNA.
DR   RefSeq; WP_001295798.1; NC_017628.1.
DR   AlphaFoldDB; D5CVJ6; -.
DR   SMR; D5CVJ6; -.
DR   KEGG; eih:ECOK1_0276; -.
DR   PATRIC; fig|714962.3.peg.276; -.
DR   HOGENOM; CLU_106652_0_0_6; -.
DR   OMA; RPREVQF; -.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR008962; PapD-like_sf.
DR   SUPFAM; SSF49354; SSF49354; 1.
PE   3: Inferred from homology;
KW   Chaperone; Fimbrium biogenesis; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..236
FT                   /note="Probable fimbrial chaperone EcpE"
FT                   /id="PRO_0000429540"
SQ   SEQUENCE   236 AA;  26620 MW;  C4E4CA0407AFFFCA CRC64;
     MFRRRGVTLT KALLTVVCML AAPLTQAISV GNLTFSLPSE TDFVSKRVVN NNKSARIYRI
     AISAIDSPGS SELRTRPVDG ELLFAPRQLA LQAGESEYFK FYYHGPRDNR ERYYRVSFRE
     VPTRNLTKRS PSGGEVSTEP VVVMDTILVV RPRQVQFKWS FDQVTGTVSN TGNTWFKLLI
     KPGCDSTEEE GDAWYLRPGD VVHQPELRQP GNHYLVYNDK FIKISDSCPA KPPSAD