ID   ECPE_ECOL6              Reviewed;         236 AA.
AC   Q8CWC2;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   09-JUL-2014, sequence version 2.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Probable fimbrial chaperone EcpE;
DE   Flags: Precursor;
GN   Name=ecpE; Synonyms=yagV; OrderedLocusNames=c0400;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli common
CC       pilus (ECP). ECP is found in both commensal and pathogenic strains and
CC       plays a dual role in early-stage biofilm development and host cell
CC       recognition (By similarity). {ECO:0000250}.
CC   -!- INDUCTION: Negatively regulated by H-NS. Positively regulated by IHF
CC       and EcpR (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EcpB/EcpE family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN78881.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE014075; AAN78881.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_001295798.1; NC_004431.1.
DR   AlphaFoldDB; Q8CWC2; -.
DR   SMR; Q8CWC2; -.
DR   STRING; 199310.c0400; -.
DR   EnsemblBacteria; AAN78881; AAN78881; c0400.
DR   KEGG; ecc:c0400; -.
DR   eggNOG; COG3121; Bacteria.
DR   HOGENOM; CLU_106652_0_0_6; -.
DR   BioCyc; ECOL199310:C0400-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR008962; PapD-like_sf.
DR   SUPFAM; SSF49354; SSF49354; 1.
PE   3: Inferred from homology;
KW   Chaperone; Fimbrium biogenesis; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..236
FT                   /note="Probable fimbrial chaperone EcpE"
FT                   /id="PRO_0000429541"
SQ   SEQUENCE   236 AA;  26620 MW;  C4E4CA0407AFFFCA CRC64;
     MFRRRGVTLT KALLTVVCML AAPLTQAISV GNLTFSLPSE TDFVSKRVVN NNKSARIYRI
     AISAIDSPGS SELRTRPVDG ELLFAPRQLA LQAGESEYFK FYYHGPRDNR ERYYRVSFRE
     VPTRNLTKRS PSGGEVSTEP VVVMDTILVV RPRQVQFKWS FDQVTGTVSN TGNTWFKLLI
     KPGCDSTEEE GDAWYLRPGD VVHQPELRQP GNHYLVYNDK FIKISDSCPA KPPSAD