ID   ECPR_ECOSM              Reviewed;         196 AA.
AC   B1LHW0;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-APR-2009, sequence version 2.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=HTH-type transcriptional regulator EcpR;
GN   Name=ecpR; Synonyms=matA; OrderedLocusNames=EcSMS35_0320;
OS   Escherichia coli (strain SMS-3-5 / SECEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=439855;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SMS-3-5 / SECEC;
RX   PubMed=18708504; DOI=10.1128/jb.00661-08;
RA   Fricke W.F., Wright M.S., Lindell A.H., Harkins D.M., Baker-Austin C.,
RA   Ravel J., Stepanauskas R.;
RT   "Insights into the environmental resistance gene pool from the genome
RT   sequence of the multidrug-resistant environmental isolate Escherichia coli
RT   SMS-3-5.";
RL   J. Bacteriol. 190:6779-6794(2008).
CC   -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli common
CC       pilus (ECP). ECP is found in both commensal and pathogenic strains and
CC       plays a dual role in early-stage biofilm development and host cell
CC       recognition. Positively regulates the expression of the ecp operon (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: Negatively regulated by H-NS. Positively autoregulated. Also
CC       positively regulated by IHF (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the EcpR/MatA family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ACB19272.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000970; ACB19272.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; B1LHW0; -.
DR   SMR; B1LHW0; -.
DR   EnsemblBacteria; ACB19272; ACB19272; EcSMS35_0320.
DR   KEGG; ecm:EcSMS35_0320; -.
DR   HOGENOM; CLU_128111_0_0_6; -.
DR   Proteomes; UP000007011; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..196
FT                   /note="HTH-type transcriptional regulator EcpR"
FT                   /id="PRO_0000369176"
FT   DOMAIN          138..196
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        162..181
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
SQ   SEQUENCE   196 AA;  23299 MW;  424D68D2B471154B CRC64;
     MTWQNDYSRD YEVKNHMECQ NRSDKYIWSP HDAYFYKGLS ELIVDIDRLI YLSLEKIRKD
     FVFINLNTDS LTEFINRDNE WLSAVKGKQV VLIAARKSEA LANYWYYNSN IRGVVYAGLS
     RDIRKELAYV INGRFLRKDI KKDKITDREM EIIRMTAQGM LPKSIARIEN CSVKTVYTHR
     RNAEAKLYSK LYKLVQ