ID   ECPR_KLEP7              Reviewed;         180 AA.
AC   A6T571;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=HTH-type transcriptional regulator EcpR;
GN   Name=ecpR; Synonyms=matA; OrderedLocusNames=KPN78578_02810;
GN   ORFNames=KPN_00290;
OS   Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=272620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700721 / MGH 78578;
RG   The Klebsiella pneumonia Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA   Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Part of the ecpRABCDE operon, which encodes the E.coli common
CC       pilus (ECP). ECP plays a dual role in early-stage biofilm development
CC       and host cell recognition. Positively regulates the expression of the
CC       ecp operon (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the EcpR/MatA family. {ECO:0000305}.
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DR   EMBL; CP000647; ABR75742.1; -; Genomic_DNA.
DR   RefSeq; WP_004144585.1; NC_009648.1.
DR   AlphaFoldDB; A6T571; -.
DR   SMR; A6T571; -.
DR   STRING; 272620.KPN_00290; -.
DR   EnsemblBacteria; ABR75742; ABR75742; KPN_00290.
DR   GeneID; 64296863; -.
DR   KEGG; kpn:KPN_00290; -.
DR   HOGENOM; CLU_128111_0_0_6; -.
DR   OMA; CIWPAHD; -.
DR   Proteomes; UP000000265; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..180
FT                   /note="HTH-type transcriptional regulator EcpR"
FT                   /id="PRO_0000369188"
FT   DOMAIN          122..180
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
FT   DNA_BIND        146..165
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00411"
SQ   SEQUENCE   180 AA;  21179 MW;  8B007C245CD55CAD CRC64;
     MEYKSCSDKY IWSADDSYFY KGLSELIVDI DELIYLSLEK IRKDFVFINL NTASLNEFIR
     RDSEWLSAVK GKQVVLIAAR KSEALANYWY YNSDIRGVVY VGLSRDIRKE LAYVINGRFL
     RKDIKKDKIT DREMKIIRMT AQGMQPKSIA RIENCSVKTV YTHRRNAEAK LYSKIYKLVQ