ID   ECR_CHITE               Reviewed;         536 AA.
AC   P49882;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   25-MAY-2022, entry version 109.
DE   RecName: Full=Ecdysone receptor;
DE   AltName: Full=20-hydroxy-ecdysone receptor;
DE            Short=20E receptor;
DE   AltName: Full=EcRH;
DE   AltName: Full=Ecdysteroid receptor;
DE   AltName: Full=Nuclear receptor subfamily 1 group H member 1;
GN   Name=EcR; Synonyms=NR1H1;
OS   Chironomus tentans (Midge) (Camptochironomus tentans).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea; Chironomidae;
OC   Chironominae; Chironomus.
OX   NCBI_TaxID=7153;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8485513; DOI=10.1016/0965-1748(93)90089-b;
RA   Imhof M.O., Rusconi S., Lezzi M.;
RT   "Cloning of a Chironomus tentans cDNA encoding a protein (cEcRH) homologous
RT   to the Drosophila melanogaster ecdysteroid receptor (dEcR).";
RL   Insect Biochem. Mol. Biol. 23:115-124(1993).
CC   -!- FUNCTION: Receptor for ecdysone. Binds to ecdysone response elements
CC       (ECRES).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; S60739; AAC60500.1; -; mRNA.
DR   PIR; A56590; A56590.
DR   AlphaFoldDB; P49882; -.
DR   SMR; P49882; -.
DR   BindingDB; P49882; -.
DR   ChEMBL; CHEMBL2366579; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0035100; F:ecdysone binding; IEA:InterPro.
DR   GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0035076; P:ecdysone receptor-mediated signaling pathway; IEA:InterPro.
DR   CDD; cd06938; NR_LBD_EcR; 1.
DR   Gene3D; 1.10.565.10; -; 1.
DR   Gene3D; 3.30.50.10; -; 1.
DR   InterPro; IPR003069; Ecdystd_rcpt.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR041889; NR_LBD_EcR.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR01283; ECDYSTEROIDR.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF48508; SSF48508; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Receptor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..536
FT                   /note="Ecdysone receptor"
FT                   /id="PRO_0000053527"
FT   DOMAIN          278..514
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01189"
FT   DNA_BIND        115..187
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         115..135
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   ZN_FING         151..175
FT                   /note="NR C4-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00407"
FT   REGION          1..114
FT                   /note="Modulating"
FT                   /evidence="ECO:0000255"
FT   REGION          77..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   536 AA;  61193 MW;  196E0C1CB8048CA7 CRC64;
     MKTENLIVTT VKVEPLNYAS QSFGDNNIYG GATKKQRLES DEWMNHNQTN MNLESSNMNH
     NTISGFSSPD VNYEAYSPNS KLDDGNMSVH MGDGLDGKKS SSKKGPVPRQ QEELCLVCGD
     RASGYHYNAL TCEGCKGFFR RSVTKNAVYC CKFGHECEMD MYMRRKCQEC RLKKCLAVGM
     RPECVVPENQ CAIKRKEKKA QKEKDKVPGI VGSNTSSSSL LNQSLNNGSL KNLEISYREE
     LLEQLMKCDP PPHPMQQLLP EKLLMENRAK GTPQLTANQV AVIYKLIWYQ DGYEQPSEED
     LKRITTELEE EEDQEHEANF RYITEVTILT VQLIVEFAKG LPAFIKIPQE DQITLLKACS
     SEVMMLRMAR RYDHDSDSIL FANNTAYTKQ TYQLAGMEET IDDLLHFCRQ MYALSIDNVE
     YALLTAIVIF SDRPGLEKAE MVDIIQSYYT ETLKVYIVNR HGGESRCSVQ FAKLLGILTE
     LRTMGNKNSE MCFSLKLRNR KLPRFLEEVW DVGDVNNQTT ATTNTENIVR ERINRN