ECSA_BACSU
ID ECSA_BACSU Reviewed; 247 AA.
AC P55339;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=ABC-type transporter ATP-binding protein EcsA;
GN Name=ecsA; Synonyms=prsT, yhaD; OrderedLocusNames=BSU10040;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=8581172; DOI=10.1099/13500872-142-1-71;
RA Leskela S., Kontinen V.P., Sarvas M.;
RT "Molecular analysis of an operon in Bacillus subtilis encoding a novel ABC
RT transporter with a role in exoprotein production, sporulation and
RT competence.";
RL Microbiology 142:71-77(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9579061; DOI=10.1099/00221287-144-4-859;
RA Noback M.A., Holsappel S., Kiewiet R., Terpstra P., Wambutt R., Wedler H.,
RA Venema G., Bron S.;
RT "The 172 kb prkA-addAB region from 83 degrees to 97 degrees of the Bacillus
RT subtilis chromosome contains several dysfunctional genes, the glyB marker,
RT many genes encoding transporter proteins, and the ubiquitous hit gene.";
RL Microbiology 144:859-875(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
CC -!- FUNCTION: Has a role in exoprotein production, sporulation and
CC competence.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. {ECO:0000305}.
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DR EMBL; X87807; CAA61074.1; -; Genomic_DNA.
DR EMBL; Y14077; CAA74409.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB12844.1; -; Genomic_DNA.
DR PIR; F69619; F69619.
DR RefSeq; NP_388885.1; NC_000964.3.
DR RefSeq; WP_003233230.1; NZ_JNCM01000035.1.
DR AlphaFoldDB; P55339; -.
DR SMR; P55339; -.
DR STRING; 224308.BSU10040; -.
DR TCDB; 3.A.1.143.1; the atp-binding cassette (abc) superfamily.
DR PaxDb; P55339; -.
DR PRIDE; P55339; -.
DR EnsemblBacteria; CAB12844; CAB12844; BSU_10040.
DR GeneID; 936293; -.
DR KEGG; bsu:BSU10040; -.
DR PATRIC; fig|224308.179.peg.1080; -.
DR eggNOG; COG1131; Bacteria.
DR InParanoid; P55339; -.
DR OMA; IMCAFLV; -.
DR PhylomeDB; P55339; -.
DR BioCyc; BSUB:BSU10040-MON; -.
DR PRO; PR:P55339; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0030420; P:establishment of competence for transformation; IEA:UniProtKB-KW.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Competence; Nucleotide-binding; Reference proteome;
KW Sporulation; Transport.
FT CHAIN 1..247
FT /note="ABC-type transporter ATP-binding protein EcsA"
FT /id="PRO_0000092320"
FT DOMAIN 4..234
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 36..43
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT MUTAGEN 164
FT /note="G->E: In ecsA-26; exoamylase and other exoenzymes
FT decrease, competence- and sporulation-deficient phenotype."
SQ SEQUENCE 247 AA; 27722 MW; 0FB1D5A2540B9739 CRC64;
MSLLSVKDLT GGYTRNPVLK NVSFTLEPNQ IVGLIGLNGA GKSTTIRHII GLMDPHKGSI
ELNGKTFAED PEGYRSQFTY IPETPVLYEE LTLMEHLELT AMAYGLSKET MEKRLPPLLK
EFRMEKRLKW FPAHFSKGMK QKVMIMCAFL AEPALYIIDE PFLGLDPLAI NALLERMNEA
KKGGASVLMS THILATAERY CDSFIILHNG EVRARGTLSE LREQFGMKDA ALDDLYLELT
KEDAGHE
