ID   ECSIT_BOVIN             Reviewed;         433 AA.
AC   Q3SX05;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial {ECO:0000250|UniProtKB:Q9BQ95};
DE   Flags: Precursor;
GN   Name=ECSIT {ECO:0000250|UniProtKB:Q9BQ95};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Uterus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adapter protein of the Toll-like and IL-1 receptor signaling
CC       pathway that is involved in the activation of NF-kappa-B via MAP3K1.
CC       Promotes proteolytic activation of MAP3K1. Involved in the BMP
CC       signaling pathway. Required for normal embryonic development (By
CC       similarity). {ECO:0000250}.
CC   -!- FUNCTION: As part of the MCIA complex, involved in the assembly of the
CC       mitochondrial complex I. {ECO:0000250|UniProtKB:Q9BQ95}.
CC   -!- SUBUNIT: Interacts with MAP3K1, SMAD4 and TRAF6. Interacts with SMAD1
CC       only after BMP4-treatment (By similarity). Part of the mitochondrial
CC       complex I assembly/MCIA complex that comprises at least the core
CC       subunits TMEM126B, NDUFAF1, ECSIT and ACAD9 and complement subunits
CC       such as COA1 and TMEM186. Interacts with NDUFAF1. Interacts with ACAD9
CC       (By similarity). Interacts with TRIM59 (By similarity). Interacts with
CC       TMEM70 and TMEM242 (By similarity). {ECO:0000250|UniProtKB:Q9BQ95,
CC       ECO:0000250|UniProtKB:Q9QZH6}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ECSIT family. {ECO:0000305}.
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DR   EMBL; BC104572; AAI04573.1; -; mRNA.
DR   RefSeq; NP_001029458.1; NM_001034286.1.
DR   RefSeq; XP_010805109.1; XM_010806807.2.
DR   AlphaFoldDB; Q3SX05; -.
DR   STRING; 9913.ENSBTAP00000020029; -.
DR   PaxDb; Q3SX05; -.
DR   PRIDE; Q3SX05; -.
DR   Ensembl; ENSBTAT00000020029; ENSBTAP00000020029; ENSBTAG00000015049.
DR   GeneID; 507245; -.
DR   KEGG; bta:507245; -.
DR   CTD; 51295; -.
DR   VEuPathDB; HostDB:ENSBTAG00000015049; -.
DR   VGNC; VGNC:28313; ECSIT.
DR   eggNOG; KOG3941; Eukaryota.
DR   GeneTree; ENSGT00390000005147; -.
DR   HOGENOM; CLU_046917_0_0_1; -.
DR   InParanoid; Q3SX05; -.
DR   OMA; FGQHNVH; -.
DR   OrthoDB; 995360at2759; -.
DR   TreeFam; TF314943; -.
DR   Reactome; R-BTA-166058; MyD88:MAL(TIRAP) cascade initiated on plasma membrane.
DR   Reactome; R-BTA-6799198; Complex I biogenesis.
DR   Reactome; R-BTA-975138; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
DR   Reactome; R-BTA-975871; MyD88 cascade initiated on plasma membrane.
DR   Proteomes; UP000009136; Chromosome 7.
DR   Bgee; ENSBTAG00000015049; Expressed in infraspinatus muscle and 104 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0051341; P:regulation of oxidoreductase activity; ISS:UniProtKB.
DR   GO; GO:0061635; P:regulation of protein complex stability; ISS:UniProtKB.
DR   InterPro; IPR029342; ECIST_C.
DR   InterPro; IPR010418; ECSIT.
DR   PANTHER; PTHR13113; PTHR13113; 1.
DR   Pfam; PF06239; ECSIT; 1.
DR   Pfam; PF14784; ECSIT_C; 1.
DR   SMART; SM01284; ECSIT_Cterm; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Immunity; Innate immunity; Mitochondrion; Nucleus;
KW   Reference proteome; Transit peptide.
FT   TRANSIT         1..48
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           49..433
FT                   /note="Evolutionarily conserved signaling intermediate in
FT                   Toll pathway, mitochondrial"
FT                   /id="PRO_0000291984"
FT   REGION          36..63
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          397..433
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   433 AA;  49251 MW;  8698F263AB81E449 CRC64;
     MSWAQAILLA RGASRGWGGI CSTALTGAPF SQVPPQAPRG LRCSAAAHNP DSSLVPHPPE
     PPRRPVKALA VHEELFRPAL DGARNKANFV RAVQNFTEYN VHKRGHVDFI YLALRKMREY
     GVERDLSVYN LLLDIFPKEV FRPRNIFHSI FLHYPRQQEC GIAVLEQMEN HGVMPNKETE
     FLLLQIFGRK SYPMLKLVRM KLWFTRFKNI NPFPVPRDLP QDPVDLASLA LRHMEPDLSA
     RVTTYQMPLL KDSPNAMDPT ETHIVGIQSP EQQSALARHD PARPIFVEGP FSLWLRDKCV
     YYHILRADLL PPEEREVEEI PEEWNLYYPM QLDLAYGRSS WDDYEFNIDE VEEGPVFAIC
     VAGAHDQATL AKWIQGLQET NPALARIPVV FRLSGSSGEL LPSSSELEEP PPPPPEGQEE
     EEDSQQRQQQ GQS