ID   ECSIT_DANRE             Reviewed;         452 AA.
AC   Q08CK1;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial;
DE   Flags: Precursor;
GN   Name=ecsit; ORFNames=zgc:152999;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adapter protein of the Toll-like and IL-1 receptor signaling
CC       pathway that is involved in the activation of NF-kappa-B.
CC   -!- FUNCTION: Required for efficient assembly of mitochondrial
CC       NADH:ubiquinone oxidoreductase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ECSIT family. {ECO:0000305}.
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DR   EMBL; BC124208; AAI24209.1; -; mRNA.
DR   AlphaFoldDB; Q08CK1; -.
DR   STRING; 7955.ENSDARP00000124710; -.
DR   PaxDb; Q08CK1; -.
DR   PRIDE; Q08CK1; -.
DR   ZFIN; ZDB-GENE-030131-1332; ecsit.
DR   eggNOG; KOG3941; Eukaryota.
DR   InParanoid; Q08CK1; -.
DR   PhylomeDB; Q08CK1; -.
DR   Reactome; R-DRE-166058; MyD88:MAL(TIRAP) cascade initiated on plasma membrane.
DR   Reactome; R-DRE-6799198; Complex I biogenesis.
DR   Reactome; R-DRE-975138; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
DR   Reactome; R-DRE-975871; MyD88 cascade initiated on plasma membrane.
DR   PRO; PR:Q08CK1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0051341; P:regulation of oxidoreductase activity; ISS:UniProtKB.
DR   GO; GO:0061635; P:regulation of protein complex stability; ISS:UniProtKB.
DR   InterPro; IPR029342; ECIST_C.
DR   InterPro; IPR010418; ECSIT.
DR   PANTHER; PTHR13113; PTHR13113; 1.
DR   Pfam; PF06239; ECSIT; 1.
DR   Pfam; PF14784; ECSIT_C; 1.
DR   SMART; SM01284; ECSIT_Cterm; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Immunity; Innate immunity; Mitochondrion; Nucleus;
KW   Reference proteome; Transit peptide.
FT   TRANSIT         1..58
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           59..452
FT                   /note="Evolutionarily conserved signaling intermediate in
FT                   Toll pathway, mitochondrial"
FT                   /id="PRO_0000291989"
FT   REGION          413..452
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        417..452
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   452 AA;  52186 MW;  937D52ADC9A6E641 CRC64;
     MSASHHLLRL QCVRCVSHFL GTPVRQVILP GRAHLQTPGS QHIYVQLLRP FHRSAVCSTD
     RQNRTDIEKL VEDETHHKDK TLVTHDDIFD RAAGDSKTKV EFNRVVDVFK SKDIRRRGHV
     EFIYAALKKM PEFGVECDVT VYNKLLDVFP KEVFVPQNFI QRMFNHYPRQ QECGVQVLEQ
     MENYGVMPNI ETKVLLVQIF GEKSHPIRKF QRIMYWFPKF KHTNPYPVPH VLPSDPVDLA
     QFSLTRIAAD LDAKITIYQY PSTDITETGE EITRPHIVGI QSPDQRSLLA KHNPCKPVFV
     EGPYPLWLRQ KCVHYYLLRA DPIPPEEKVE EEIDPEMICP EQSLFFPQRV ELDLKVDMGD
     DHSFNVDEVE EGAVYAMCMA GQGDQATLSQ WISGLQETCP ILGQIPTVFR LESGPRELQT
     STDDHQRPEQ EAETDQIIED DEEPRHSRGV KQ