ID   ECSIT_MACFA             Reviewed;         430 AA.
AC   Q4R5Q4;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial {ECO:0000250|UniProtKB:Q9BQ95};
DE   Flags: Precursor;
GN   Name=ECSIT {ECO:0000250|UniProtKB:Q9BQ95}; ORFNames=QccE-10646;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adapter protein of the Toll-like and IL-1 receptor signaling
CC       pathway that is involved in the activation of NF-kappa-B via MAP3K1.
CC       Promotes proteolytic activation of MAP3K1. Involved in the BMP
CC       signaling pathway. Required for normal embryonic development (By
CC       similarity). {ECO:0000250}.
CC   -!- FUNCTION: As part of the MCIA complex, involved in the assembly of the
CC       mitochondrial complex I. {ECO:0000250|UniProtKB:Q9BQ95}.
CC   -!- SUBUNIT: Interacts with MAP3K1, SMAD4 and TRAF6. Interacts with SMAD1
CC       only after BMP4-treatment (By similarity). Part of the mitochondrial
CC       complex I assembly/MCIA complex that comprises at least the core
CC       subunits TMEM126B, NDUFAF1, ECSIT and ACAD9 and complement subunits
CC       such as COA1 and TMEM186. Interacts with NDUFAF1. Interacts with ACAD9
CC       (By similarity). Interacts with TRIM59 (By similarity). Interacts with
CC       TMEM70 and TMEM242 (By similarity). {ECO:0000250|UniProtKB:Q9BQ95,
CC       ECO:0000250|UniProtKB:Q9QZH6}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ECSIT family. {ECO:0000305}.
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DR   EMBL; AB169489; BAE01571.1; -; mRNA.
DR   RefSeq; NP_001306339.1; NM_001319410.1.
DR   RefSeq; XP_005588112.1; XM_005588055.2.
DR   RefSeq; XP_015296226.1; XM_015440740.1.
DR   RefSeq; XP_015296227.1; XM_015440741.1.
DR   AlphaFoldDB; Q4R5Q4; -.
DR   Ensembl; ENSMFAT00000005429; ENSMFAP00000031215; ENSMFAG00000036660.
DR   GeneID; 107126402; -.
DR   KEGG; mcf:107126402; -.
DR   CTD; 51295; -.
DR   GeneTree; ENSGT00390000005147; -.
DR   OrthoDB; 995360at2759; -.
DR   Proteomes; UP000233100; Chromosome 19.
DR   Bgee; ENSMFAG00000036660; Expressed in heart and 13 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0051341; P:regulation of oxidoreductase activity; ISS:UniProtKB.
DR   GO; GO:0061635; P:regulation of protein complex stability; ISS:UniProtKB.
DR   InterPro; IPR029342; ECIST_C.
DR   InterPro; IPR010418; ECSIT.
DR   PANTHER; PTHR13113; PTHR13113; 1.
DR   Pfam; PF06239; ECSIT; 1.
DR   Pfam; PF14784; ECSIT_C; 1.
DR   SMART; SM01284; ECSIT_Cterm; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Immunity; Innate immunity; Mitochondrion; Nucleus;
KW   Reference proteome; Transit peptide.
FT   TRANSIT         1..48
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           49..430
FT                   /note="Evolutionarily conserved signaling intermediate in
FT                   Toll pathway, mitochondrial"
FT                   /id="PRO_0000291986"
FT   REGION          41..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          400..430
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        46..60
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   430 AA;  49091 MW;  473D33A0C7BC2A1D CRC64;
     MSWVQATLLA RGLCRAWGGI CRAALPGTSI SQVPRQLPRG LHCSAAPHSS EQSLVSSPPE
     PRQRPTKALV PYEDLFGQAP SGERDKASFL QAVQKFGEHS VRKRGHIDFI YLALRKMREY
     GVERDLAVYN QLLDIFPKEV FRPRNVIQRI FVHYPRQQEC GIAVLEQMES HGVMPNKETE
     FLLIQIFGRK SYPMLKLLRL KMWFPRFMNI NPFPVPRDLS QDPVELATFG LRHMEPDLSA
     RVTIYQVPLP KDSTGAADPP QPHIVGIQSP DQQAALARHN PARPIFVEGP FSLWLRNKCV
     YYHILRADLL PPEEREVEET PEEWNLYYPM QLDLEYSRSG WDDYEFDINE VEEGPVFAMC
     MAGAHDQATL AKWIQGLQET NPTLAQIPVV FRLTRATGEL HTSSAGLEEP PPPEDHEEDD
     SRQRQQQGQS