ID   ECSIT_XENLA             Reviewed;         410 AA.
AC   A2VD95;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial;
DE   Flags: Precursor;
GN   Name=ecsit;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Forelimb, and Hind limb;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adapter protein of the Toll-like and IL-1 receptor signaling
CC       pathway that is involved in the activation of NF-kappa-B.
CC   -!- FUNCTION: Required for efficient assembly of mitochondrial
CC       NADH:ubiquinone oxidoreductase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ECSIT family. {ECO:0000305}.
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DR   EMBL; BC129631; AAI29632.1; -; mRNA.
DR   RefSeq; NP_001091354.1; NM_001097885.1.
DR   AlphaFoldDB; A2VD95; -.
DR   DNASU; 100037194; -.
DR   GeneID; 100037194; -.
DR   KEGG; xla:100037194; -.
DR   CTD; 100037194; -.
DR   Xenbase; XB-GENE-866520; ecsit.S.
DR   OrthoDB; 995360at2759; -.
DR   Proteomes; UP000186698; Chromosome 3S.
DR   Bgee; 100037194; Expressed in muscle tissue and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0051341; P:regulation of oxidoreductase activity; ISS:UniProtKB.
DR   GO; GO:0061635; P:regulation of protein complex stability; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR029342; ECIST_C.
DR   InterPro; IPR010418; ECSIT.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13113; PTHR13113; 1.
DR   Pfam; PF06239; ECSIT; 1.
DR   Pfam; PF14784; ECSIT_C; 1.
DR   SMART; SM01284; ECSIT_Cterm; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Immunity; Innate immunity; Mitochondrion; Nucleus;
KW   Reference proteome; Transit peptide.
FT   TRANSIT         1..33
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           34..410
FT                   /note="Evolutionarily conserved signaling intermediate in
FT                   Toll pathway, mitochondrial"
FT                   /id="PRO_0000291990"
FT   REGION          35..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          377..410
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        388..410
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   410 AA;  47585 MW;  6AA532201B63E10D CRC64;
     MRTLRFLLSA RHLSPRAKGI PVLQTLGHKA QRPMTCSLHT SQPPGPPQTT SSAGSVAPYE
     DVFKKEQRNK SNFVEVLDLY CKRDTRRRGH VEIIETALRW MPEFGVEKDL EVYNKLLDVF
     PKEIFIPQNF IQRMFNHYPR QQECAIRVLE QMEHYGITPN KQTCFLLLQI FGDRSHPIKK
     YQRMMYWFPR FKYTNPFPVP AELPADPVEL SRMCLHRIAA DLDSRVAVHQ MPYTEKCDDG
     KEQEHLHIVG IQSPSQVSLL AAHDPSTPVY VEGPFPLWLK KTCVYYYILR ADPDPMENEE
     EIDNERSFYY PLSLDIQLDR DLGDDDSFDV DDVVEGPVFA MCMAGSGDER LLGKWIRGLQ
     ETNPILGQTP VVFRLNSGPQ ELSVPQEKEA QPKQEVEEEE REPERHRMEQ