ID   ECSIT_XENTR             Reviewed;         414 AA.
AC   Q0V9C9;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial;
DE   Flags: Precursor;
GN   Name=ecsit;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Oviduct;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adapter protein of the Toll-like and IL-1 receptor signaling
CC       pathway that is involved in the activation of NF-kappa-B.
CC   -!- FUNCTION: Required for efficient assembly of mitochondrial
CC       NADH:ubiquinone oxidoreductase. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC       Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ECSIT family. {ECO:0000305}.
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DR   EMBL; BC121633; AAI21634.1; -; mRNA.
DR   RefSeq; NP_001072411.1; NM_001078943.1.
DR   RefSeq; XP_012808630.1; XM_012953176.2.
DR   AlphaFoldDB; Q0V9C9; -.
DR   STRING; 8364.ENSXETP00000036500; -.
DR   PaxDb; Q0V9C9; -.
DR   PRIDE; Q0V9C9; -.
DR   DNASU; 779865; -.
DR   Ensembl; ENSXETT00000036500; ENSXETP00000036500; ENSXETG00000016738.
DR   GeneID; 779865; -.
DR   KEGG; xtr:779865; -.
DR   CTD; 51295; -.
DR   Xenbase; XB-GENE-853811; ecsit.
DR   eggNOG; KOG3941; Eukaryota.
DR   HOGENOM; CLU_046917_0_0_1; -.
DR   InParanoid; Q0V9C9; -.
DR   OrthoDB; 995360at2759; -.
DR   Reactome; R-XTR-166058; MyD88:MAL(TIRAP) cascade initiated on plasma membrane.
DR   Reactome; R-XTR-6799198; Complex I biogenesis.
DR   Reactome; R-XTR-975138; TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.
DR   Reactome; R-XTR-975871; MyD88 cascade initiated on plasma membrane.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000016738; Expressed in skeletal muscle tissue and 12 other tissues.
DR   ExpressionAtlas; Q0V9C9; baseline.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0051341; P:regulation of oxidoreductase activity; ISS:UniProtKB.
DR   GO; GO:0061635; P:regulation of protein complex stability; ISS:UniProtKB.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR029342; ECIST_C.
DR   InterPro; IPR010418; ECSIT.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   PANTHER; PTHR13113; PTHR13113; 1.
DR   Pfam; PF06239; ECSIT; 1.
DR   Pfam; PF14784; ECSIT_C; 1.
DR   SMART; SM01284; ECSIT_Cterm; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Immunity; Innate immunity; Mitochondrion; Nucleus;
KW   Reference proteome; Transit peptide.
FT   TRANSIT         1..27
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..414
FT                   /note="Evolutionarily conserved signaling intermediate in
FT                   Toll pathway, mitochondrial"
FT                   /id="PRO_0000291991"
FT   REGION          379..414
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   414 AA;  47644 MW;  CD3FA97FC3249CCE CRC64;
     MRTLRFLISA RHLCARGRGI PAGQALGTGN NAQKQVTCCL HTSPPPGPPQ ATSSAGSVTP
     YEDVFQREQR NKASFVEVLD LYCNRDVRRR GHVEIIEAAL RWMTEFGVEK DLEVYNKLLD
     VFPKEVFVPQ NYIQRMFNHY PRQQECAIRV LEQMENYGIT PNKQTCFLLL QIFGARSHPI
     RKYQRMMYWF PRFKHTNPFP VPAELPADPV ELSRMCLHRI ANDLDSRVAV YQMPYTEKCD
     DGKEREHLHV VGIQSPSQVS LLAAHNPSTP VYVEGPFPLW LRKTCVYYYI LRADPDPMRK
     EEEIDNERSL YYPLSLDLEL DRDLGDDDSF DVDDVEEGPV FAMCMAGSGD ELLLGKWIRG
     LQETNPILGQ TPVVFRLNSG PQELSVPQEK EAEPKGELED DEGEREPERR RMEQ