ID   ECT1_ENCCU              Reviewed;         322 AA.
AC   Q8SQW6;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Probable ethanolamine-phosphate cytidylyltransferase;
DE            EC=2.7.7.14;
DE   AltName: Full=CTP:phosphoethanolamine cytidylyltransferase;
DE   AltName: Full=Phosphorylethanolamine transferase;
GN   Name=MUQ1; OrderedLocusNames=ECU11_0870;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], AND
RP   DEVELOPMENTAL STAGE.
RX   PubMed=16691553; DOI=10.1002/pmic.200500796;
RA   Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.;
RT   "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi
RT   (microsporidia): a reference map for proteins expressed in late sporogonial
RT   stages.";
RL   Proteomics 6:3625-3635(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=CTP + H(+) + phosphoethanolamine = CDP-ethanolamine +
CC         diphosphate; Xref=Rhea:RHEA:24592, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37563, ChEBI:CHEBI:57876,
CC         ChEBI:CHEBI:58190; EC=2.7.7.14;
CC   -!- PATHWAY: Phospholipid metabolism; phosphatidylethanolamine
CC       biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.
CC   -!- DEVELOPMENTAL STAGE: Expressed in late sporogonial stages.
CC       {ECO:0000269|PubMed:16691553}.
CC   -!- SIMILARITY: Belongs to the cytidylyltransferase family. {ECO:0000305}.
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DR   EMBL; AL590450; CAD25997.1; -; Genomic_DNA.
DR   RefSeq; NP_586393.1; NM_001042226.1.
DR   AlphaFoldDB; Q8SQW6; -.
DR   SMR; Q8SQW6; -.
DR   STRING; 284813.Q8SQW6; -.
DR   PRIDE; Q8SQW6; -.
DR   GeneID; 860046; -.
DR   KEGG; ecu:ECU11_0870; -.
DR   VEuPathDB; MicrosporidiaDB:ECU11_0870; -.
DR   HOGENOM; CLU_031246_2_2_1; -.
DR   InParanoid; Q8SQW6; -.
DR   OMA; AAHGSDI; -.
DR   OrthoDB; 871204at2759; -.
DR   UniPathway; UPA00558; UER00742.
DR   Proteomes; UP000000819; Chromosome XI.
DR   GO; GO:0004306; F:ethanolamine-phosphate cytidylyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006646; P:phosphatidylethanolamine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.40.50.620; -; 2.
DR   InterPro; IPR004821; Cyt_trans-like.
DR   InterPro; IPR044608; Ect1/PCYT2.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR45780; PTHR45780; 1.
DR   Pfam; PF01467; CTP_transf_like; 2.
DR   TIGRFAMs; TIGR00125; cyt_tran_rel; 2.
DR   PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
PE   1: Evidence at protein level;
KW   Lipid biosynthesis; Lipid metabolism; Nucleotidyltransferase;
KW   Phospholipid biosynthesis; Phospholipid metabolism; Reference proteome;
KW   Transferase.
FT   CHAIN           1..322
FT                   /note="Probable ethanolamine-phosphate
FT                   cytidylyltransferase"
FT                   /id="PRO_0000381749"
SQ   SEQUENCE   322 AA;  36594 MW;  6F96CD2904921F32 CRC64;
     MASHEIQKVW ADGCFDMFHY GHANALRQSK ALGDYLIAGV HSSLSINQEK GLPVMEDEER
     YEVVEGCRYV DEVVRDAPFV TQTSMIKEYG VSIVAHGNDI VLDSSGQDSY CQVRRMGIFR
     EVERTFGIST TEIVGRMMLK NRGSWLDGEN GESSKDSGYH DRLLSLFMSS MGREKRGKVV
     FMDGNFDLFH AGHVASLRIA RGMGDYLIVG IHDDETTKEY TRSYPVLSTK ERMLTLMACR
     YVDEIVVSPY LVGSEFIKRH GIDVVAPSFD SKDLSRYDGI KDVVEHSYAE NRFNYLSAEH
     IVNRIISNYQ DYANRQKKRT GK