ECTA_BORBR
ID ECTA_BORBR Reviewed; 186 AA.
AC Q7WHI7;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=L-2,4-diaminobutyric acid acetyltransferase;
DE Short=DABA acetyltransferase;
DE EC=2.3.1.178;
GN Name=ectA; OrderedLocusNames=BB3220;
OS Bordetella bronchiseptica (strain ATCC BAA-588 / NCTC 13252 / RB50)
OS (Alcaligenes bronchisepticus).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae; Bordetella.
OX NCBI_TaxID=257310;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-588 / NCTC 13252 / RB50;
RX PubMed=12910271; DOI=10.1038/ng1227;
RA Parkhill J., Sebaihia M., Preston A., Murphy L.D., Thomson N.R.,
RA Harris D.E., Holden M.T.G., Churcher C.M., Bentley S.D., Mungall K.L.,
RA Cerdeno-Tarraga A.-M., Temple L., James K.D., Harris B., Quail M.A.,
RA Achtman M., Atkin R., Baker S., Basham D., Bason N., Cherevach I.,
RA Chillingworth T., Collins M., Cronin A., Davis P., Doggett J., Feltwell T.,
RA Goble A., Hamlin N., Hauser H., Holroyd S., Jagels K., Leather S.,
RA Moule S., Norberczak H., O'Neil S., Ormond D., Price C., Rabbinowitsch E.,
RA Rutter S., Sanders M., Saunders D., Seeger K., Sharp S., Simmonds M.,
RA Skelton J., Squares R., Squares S., Stevens K., Unwin L., Whitehead S.,
RA Barrell B.G., Maskell D.J.;
RT "Comparative analysis of the genome sequences of Bordetella pertussis,
RT Bordetella parapertussis and Bordetella bronchiseptica.";
RL Nat. Genet. 35:32-40(2003).
CC -!- FUNCTION: Catalyzes the acetylation of L-2,4-diaminobutyrate (DABA) to
CC gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) with acetyl
CC coenzyme A. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetyl-CoA + L-2,4-diaminobutanoate = (2S)-4-acetamido-2-
CC aminobutanoate + CoA + H(+); Xref=Rhea:RHEA:16901, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:58761,
CC ChEBI:CHEBI:58929; EC=2.3.1.178;
CC -!- PATHWAY: Amine and polyamine biosynthesis; ectoine biosynthesis; L-
CC ectoine from L-aspartate 4-semialdehyde: step 2/3.
CC -!- SIMILARITY: Belongs to the acetyltransferase family. EctA subfamily.
CC {ECO:0000305}.
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DR EMBL; BX640446; CAE33712.1; -; Genomic_DNA.
DR RefSeq; WP_003810598.1; NC_002927.3.
DR AlphaFoldDB; Q7WHI7; -.
DR SMR; Q7WHI7; -.
DR STRING; 257310.BB3220; -.
DR EnsemblBacteria; CAE33712; CAE33712; BB3220.
DR GeneID; 56479330; -.
DR GeneID; 66439337; -.
DR KEGG; bbr:BB3220; -.
DR eggNOG; COG0456; Bacteria.
DR HOGENOM; CLU_111896_0_0_4; -.
DR OMA; DGAAIWR; -.
DR OrthoDB; 1826274at2; -.
DR UniPathway; UPA00067; UER00122.
DR Proteomes; UP000001027; Chromosome.
DR GO; GO:0033816; F:diaminobutyrate acetyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008080; F:N-acetyltransferase activity; IEA:InterPro.
DR GO; GO:0019491; P:ectoine biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR012772; Ectoine_EctA.
DR InterPro; IPR000182; GNAT_dom.
DR Pfam; PF00583; Acetyltransf_1; 1.
DR SUPFAM; SSF55729; SSF55729; 1.
DR TIGRFAMs; TIGR02406; ectoine_EctA; 1.
DR PROSITE; PS51186; GNAT; 1.
PE 3: Inferred from homology;
KW Acyltransferase; Transferase.
FT CHAIN 1..186
FT /note="L-2,4-diaminobutyric acid acetyltransferase"
FT /id="PRO_0000220083"
FT DOMAIN 24..179
FT /note="N-acetyltransferase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00532"
SQ SEQUENCE 186 AA; 20692 MW; 8DCA9AE45364F738 CRC64;
MRKDETSNTS PDISAAQPAS ALRYQLRPPR RNDGAAIHQL VSECPPLDLN SLYAYLLLCE
HHAHTCVVAE SPGGRIDGFV SAYLLPTRPD VLFVWQVAVH SRARGHRLGR AMLGHILERQ
ECRHVRHLET TVGPDNQASR RTFAGLAGER GAHVSEQPFF DRQAFGGADH DDEMLLRIGP
FTHPPH